FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060324713> ?p ?o ?g. }

• W2060324713 endingPage "195" @default.
• W2060324713 startingPage "186" @default.
• W2060324713 abstract "Antenatal steroid administration is associated with alterations in fetal kidney development and hypertension. However, a causal relationship between nephron deficit and hypertension has not been established. In this study, we measured nephron number, renal function, and blood pressure in sheep exposed antenataly to betamethasone. Pregnant sheep were given 2 betamethasone doses (0.17 mg/kg) or vehicle at 80 and 81 days gestational age and allowed to deliver at term. Data were obtained from a fetal cohort and 2 adult cohorts and were analyzed by analysis of variance (ANOVA) and/or 2 sample t test. Antenatal betamethasone induced a 26% reduction in the number of nephrons in both males and females in the absence of intrauterine growth restriction and/or prematurity. Adult males presented a reduction in glomerular filtration rate (GFR; 132 +/- 12.7 vs 114 +/- 7.0 mL/min, P < .05). Betamethasone administration was also associated with an increase in arterial blood pressure of similar magnitude in male (mean arterial pressure [MAP] in mm Hg; 98 +/- 2.7 vs 105 +/- 2.4) and female (96 +/- 1.9 vs 105 +/- 2.4) adult sheep and the increase in blood pressure preceded the decrease in GFR in the males. Furthermore, we found no significant association between the magnitude of the decrease in nephron number and the magnitude of the increase in arterial blood pressure. Our data thus support the conclusion that exposure to glucocorticoids at a time of rapid kidney growth is associated with an elevation in blood pressure that does not appear related solely to the reduction in nephron number." @default.
• W2060324713 created "2016-06-24" @default.
• W2060324713 creator A5028768610 @default.
• W2060324713 creator A5035790893 @default.
• W2060324713 creator A5073501391 @default.
• W2060324713 creator A5077763976 @default.
• W2060324713 date "2010-02-01" @default.
• W2060324713 modified "2023-10-01" @default.
• W2060324713 title "Differential Effects of Clinical Doses of Antenatal Betamethasone on Nephron Endowment and Glomerular Filtration Rate in Adult Sheep" @default.
• W2060324713 cites W1486745645 @default.
• W2060324713 cites W1902039366 @default.
• W2060324713 cites W1985887239 @default.
• W2060324713 cites W1986861479 @default.
• W2060324713 cites W1988111364 @default.
• W2060324713 cites W1995492118 @default.
• W2060324713 cites W2014757962 @default.
• W2060324713 cites W2018558315 @default.
• W2060324713 cites W2025905907 @default.
• W2060324713 cites W2031432218 @default.
• W2060324713 cites W2034961623 @default.
• W2060324713 cites W2036111976 @default.
• W2060324713 cites W2038479789 @default.
• W2060324713 cites W2041013321 @default.
• W2060324713 cites W2055228751 @default.
• W2060324713 cites W2056579555 @default.
• W2060324713 cites W2072161493 @default.
• W2060324713 cites W2080993287 @default.
• W2060324713 cites W2081140370 @default.
• W2060324713 cites W2081412553 @default.
• W2060324713 cites W2081523875 @default.
• W2060324713 cites W2085244135 @default.
• W2060324713 cites W2088407578 @default.
• W2060324713 cites W2098862906 @default.
• W2060324713 cites W2108660596 @default.
• W2060324713 cites W2127556723 @default.
• W2060324713 cites W2128815551 @default.
• W2060324713 cites W2130713036 @default.
• W2060324713 cites W2134400743 @default.
• W2060324713 cites W2140950633 @default.
• W2060324713 cites W2150715319 @default.
• W2060324713 cites W2152910359 @default.
• W2060324713 cites W2153843216 @default.
• W2060324713 cites W2155890499 @default.
• W2060324713 cites W2160252164 @default.
• W2060324713 cites W2160398153 @default.
• W2060324713 cites W96421504 @default.
• W2060324713 doi "https://doi.org/10.1177/1933719109351098" @default.
• W2060324713 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3232065" @default.
• W2060324713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19897787" @default.
• W2060324713 hasPublicationYear "2010" @default.
• W2060324713 type Work @default.
• W2060324713 sameAs 2060324713 @default.
• W2060324713 citedByCount "40" @default.
• W2060324713 countsByYear W20603247132012 @default.
• W2060324713 countsByYear W20603247132013 @default.
• W2060324713 countsByYear W20603247132014 @default.
• W2060324713 countsByYear W20603247132016 @default.
• W2060324713 countsByYear W20603247132017 @default.
• W2060324713 countsByYear W20603247132018 @default.
• W2060324713 countsByYear W20603247132019 @default.
• W2060324713 countsByYear W20603247132020 @default.
• W2060324713 countsByYear W20603247132021 @default.
• W2060324713 countsByYear W20603247132022 @default.
• W2060324713 countsByYear W20603247132023 @default.
• W2060324713 crossrefType "journal-article" @default.
• W2060324713 hasAuthorship W2060324713A5028768610 @default.
• W2060324713 hasAuthorship W2060324713A5035790893 @default.
• W2060324713 hasAuthorship W2060324713A5073501391 @default.
• W2060324713 hasAuthorship W2060324713A5077763976 @default.
• W2060324713 hasBestOaLocation W20603247132 @default.
• W2060324713 hasConcept C126322002 @default.
• W2060324713 hasConcept C134018914 @default.
• W2060324713 hasConcept C142225936 @default.
• W2060324713 hasConcept C159641895 @default.
• W2060324713 hasConcept C2776452961 @default.
• W2060324713 hasConcept C2777953023 @default.
• W2060324713 hasConcept C2778376644 @default.
• W2060324713 hasConcept C2779234561 @default.
• W2060324713 hasConcept C2781162121 @default.
• W2060324713 hasConcept C2781231759 @default.
• W2060324713 hasConcept C54355233 @default.
• W2060324713 hasConcept C71924100 @default.
• W2060324713 hasConcept C84393581 @default.
• W2060324713 hasConcept C86803240 @default.
• W2060324713 hasConceptScore W2060324713C126322002 @default.
• W2060324713 hasConceptScore W2060324713C134018914 @default.
• W2060324713 hasConceptScore W2060324713C142225936 @default.
• W2060324713 hasConceptScore W2060324713C159641895 @default.
• W2060324713 hasConceptScore W2060324713C2776452961 @default.
• W2060324713 hasConceptScore W2060324713C2777953023 @default.
• W2060324713 hasConceptScore W2060324713C2778376644 @default.
• W2060324713 hasConceptScore W2060324713C2779234561 @default.
• W2060324713 hasConceptScore W2060324713C2781162121 @default.
• W2060324713 hasConceptScore W2060324713C2781231759 @default.
• W2060324713 hasConceptScore W2060324713C54355233 @default.
• W2060324713 hasConceptScore W2060324713C71924100 @default.
• W2060324713 hasConceptScore W2060324713C84393581 @default.
• W2060324713 hasConceptScore W2060324713C86803240 @default.

• next