Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060335637> ?p ?o ?g. }
- W2060335637 endingPage "1068" @default.
- W2060335637 startingPage "1053" @default.
- W2060335637 abstract "Nowdays the endothelium is considered a key determinant of vascular health. NO is the principal mediator of all endothelial protective effects, due to its antinflammatory, antiproliferative, immunomodulatory and vasorelaxant properties. On the contrary, a growing body of evidence suggests that endothelial dysfunction is associated with cardiovascular events. Emerging data suggest that acute coronary syndromes (ACS) may involve a complex interplay between endothelial dysfunction, inflammation and thrombosis. Despite the success in reducing the mortality from acute cardiovascular events, the incidence of cardiovascular disease and its complication continues to increase. New insights into mechanisms of endothelial dysfunction, such as a better understanding of the regulation of vascular sources of oxygen radicals, may lead to novel therapeutic strategies with the potential to improve prognosis. The key pharmacological agents that improve clinical outcome in high-risk patients are statins, ACE-inhibitors or angiotensin receptor antagonists. Compelling scientific evidence suggests that these medications are effective in improving endothelial function. The present review focuses on the potential importance of benefits on endothelium of these medicaments in the management of acute coronary syndromes. Keywords: Nitric oxide, endothelial dysfunction, atherosclerosis, coronary artery disease, statin, ACEI, ARB, review" @default.
- W2060335637 created "2016-06-24" @default.
- W2060335637 creator A5040422518 @default.
- W2060335637 creator A5054282642 @default.
- W2060335637 creator A5059481316 @default.
- W2060335637 creator A5070855397 @default.
- W2060335637 date "2007-04-01" @default.
- W2060335637 modified "2023-10-17" @default.
- W2060335637 title "Restoring the Dysfunctional Endothelium" @default.
- W2060335637 cites W124719744 @default.
- W2060335637 cites W133994298 @default.
- W2060335637 cites W1502091359 @default.
- W2060335637 cites W15186908 @default.
- W2060335637 cites W1607892649 @default.
- W2060335637 cites W1678800844 @default.
- W2060335637 cites W180946569 @default.
- W2060335637 cites W1811402656 @default.
- W2060335637 cites W1821918060 @default.
- W2060335637 cites W187250248 @default.
- W2060335637 cites W1896208327 @default.
- W2060335637 cites W1899699286 @default.
- W2060335637 cites W1929084030 @default.
- W2060335637 cites W1931770906 @default.
- W2060335637 cites W1953477778 @default.
- W2060335637 cites W1953939137 @default.
- W2060335637 cites W1958652025 @default.
- W2060335637 cites W1964177840 @default.
- W2060335637 cites W1965148671 @default.
- W2060335637 cites W1965772617 @default.
- W2060335637 cites W1966557424 @default.
- W2060335637 cites W1967225427 @default.
- W2060335637 cites W1967300297 @default.
- W2060335637 cites W1968134458 @default.
- W2060335637 cites W1970807871 @default.
- W2060335637 cites W1970904231 @default.
- W2060335637 cites W1971261277 @default.
- W2060335637 cites W1971849142 @default.
- W2060335637 cites W1973433561 @default.
- W2060335637 cites W1977429372 @default.
- W2060335637 cites W1977609966 @default.
- W2060335637 cites W1978573346 @default.
- W2060335637 cites W1980445357 @default.
- W2060335637 cites W1981192304 @default.
- W2060335637 cites W1983374714 @default.
- W2060335637 cites W1984860118 @default.
- W2060335637 cites W1988774527 @default.
- W2060335637 cites W1991399493 @default.
- W2060335637 cites W1991833325 @default.
- W2060335637 cites W1994705308 @default.
- W2060335637 cites W1995827857 @default.
- W2060335637 cites W1998081634 @default.
- W2060335637 cites W199931476 @default.
- W2060335637 cites W1999589434 @default.
- W2060335637 cites W2000062790 @default.
- W2060335637 cites W2004398529 @default.
- W2060335637 cites W2006851144 @default.
- W2060335637 cites W2008299272 @default.
- W2060335637 cites W2010019554 @default.
- W2060335637 cites W2010921303 @default.
- W2060335637 cites W2011089437 @default.
- W2060335637 cites W2011142053 @default.
- W2060335637 cites W2011768242 @default.
- W2060335637 cites W2011974109 @default.
- W2060335637 cites W2012018808 @default.
- W2060335637 cites W2015372874 @default.
- W2060335637 cites W2017336019 @default.
- W2060335637 cites W2017966192 @default.
- W2060335637 cites W2020741324 @default.
- W2060335637 cites W2023992909 @default.
- W2060335637 cites W2024997159 @default.
- W2060335637 cites W2026425756 @default.
- W2060335637 cites W2026483758 @default.
- W2060335637 cites W2027406242 @default.
- W2060335637 cites W2029034420 @default.
- W2060335637 cites W2029491963 @default.
- W2060335637 cites W2029969503 @default.
- W2060335637 cites W2030747750 @default.
- W2060335637 cites W2034098187 @default.
- W2060335637 cites W2037854429 @default.
- W2060335637 cites W2039831544 @default.
- W2060335637 cites W2041747627 @default.
- W2060335637 cites W2045877680 @default.
- W2060335637 cites W2048619987 @default.
- W2060335637 cites W2048761251 @default.
- W2060335637 cites W2050548878 @default.
- W2060335637 cites W2050758464 @default.
- W2060335637 cites W2051043692 @default.
- W2060335637 cites W2051987293 @default.
- W2060335637 cites W2053292076 @default.
- W2060335637 cites W2053669774 @default.
- W2060335637 cites W2054279201 @default.
- W2060335637 cites W2054346495 @default.
- W2060335637 cites W2057116025 @default.
- W2060335637 cites W2057248093 @default.
- W2060335637 cites W2058137293 @default.
- W2060335637 cites W2058478385 @default.
- W2060335637 cites W2058950521 @default.
- W2060335637 cites W2061886045 @default.