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- W2060342258 abstract "Olfactory ensheathing cells (OECs) can remyelinate demyelinated spinal cord axons when transplanted into chemically induced demyelinated lesions. Cell transplantation is typically performed within a few days after lesion induction, i.e. during active demyelination when myelin debris, cytokine level increases and macrophage/microglia activation is extensive. Inflammatory signaling has been suggested to facilitate remyelination in cell transplant studies. In this review we discuss the migration and remyelination properties of OECs transplanted into various demyelinating lesion environments including conditions when inflammation is active and when it is largely subsided. While sharing many common properties, comparisons of the in vivo fate between OECs and SCs suggest unique properties of OECs as compared to SCs. A complicating factor in the assessment of experimental remyelination by transplantation of myelin-forming cells in general is the rapidity of endogenous myelin repair in most rodent models of demyelination. Alternative persistent demyelination models are discussed as potential tools to study both the competency of chronic demyelinated axons for remyelination and the remyelination potential of cells such as human progenitors that require longer times to mobilize and remyelinate axons. This article is part of a Special Issue entitled: Understanding olfactory ensheathing glia and their prospect for nervous system repair." @default.
- W2060342258 created "2016-06-24" @default.
- W2060342258 creator A5002181387 @default.
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- W2060342258 creator A5060562541 @default.
- W2060342258 creator A5085578045 @default.
- W2060342258 date "2011-05-01" @default.
- W2060342258 modified "2023-10-09" @default.
- W2060342258 title "Remyelination after olfactory ensheathing cell transplantation into diverse demyelinating environments" @default.
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- W2060342258 doi "https://doi.org/10.1016/j.expneurol.2011.01.010" @default.
- W2060342258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21281634" @default.
- W2060342258 hasPublicationYear "2011" @default.
- W2060342258 type Work @default.