FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060366140> ?p ?o ?g. }

• W2060366140 endingPage "42" @default.
• W2060366140 startingPage "35" @default.
• W2060366140 abstract "Hemophilia A is an X-linked bleeding disorder caused by the deficiency of factor VIII (FVIII). Exogenous FVIII is administered therapeutically, and due to a short half-life, frequent infusions are often required. Fifteen to thirty-five percent of severe hemophilia A patients develop inhibitory antibodies toward FVIII that complicate clinical management of the disease. Previously, we used phosphatidylinositol (PI) containing lipidic nanoparticles to improve the therapeutic efficacy of recombinant FVIII by reducing immunogenicity and prolonging the circulating half-life. The objective of this study is to investigate further improvements in the FVIII-PI formulation resulting from the addition of polyethylene glycol (PEG) to the particle. PEGylation was achieved by passive transfer of PEG conjugated lipid into the FVIII-PI complex. PEGylated FVIII-PI (FVIII-PI/PEG) was generated with high association efficiency. Reduced activity in vitro and improved retention of activity in the presence of antibodies suggested strong shielding of FVIII by the particle; thus, in vivo studies were conducted in hemophilia A mice. Following intravenous administration, the apparent terminal half-life was improved versus both free FVIII and FVIII-PI, but exposure determined by area under the curve was reduced. The formation of inhibitory antibodies after subcutaneous immunization with FVIII-PI/PEG was lower than free FVIII but resulted in a significant increase in inhibitors following intravenous administration. Passive transfer of PEG onto the FVIII-PI complex does not provide any therapeutic benefit." @default.
• W2060366140 created "2016-06-24" @default.
• W2060366140 creator A5036587808 @default.
• W2060366140 creator A5058107595 @default.
• W2060366140 creator A5069387057 @default.
• W2060366140 creator A5070477947 @default.
• W2060366140 creator A5086461352 @default.
• W2060366140 date "2011-12-16" @default.
• W2060366140 modified "2023-09-26" @default.
• W2060366140 title "PEGylation of a Factor VIII–Phosphatidylinositol Complex: Pharmacokinetics and Immunogenicity in Hemophilia A Mice" @default.
• W2060366140 cites W1427181771 @default.
• W2060366140 cites W1490299254 @default.
• W2060366140 cites W1513897103 @default.
• W2060366140 cites W1555210583 @default.
• W2060366140 cites W1556343014 @default.
• W2060366140 cites W1576556101 @default.
• W2060366140 cites W157872429 @default.
• W2060366140 cites W1891870091 @default.
• W2060366140 cites W1964107344 @default.
• W2060366140 cites W1964391114 @default.
• W2060366140 cites W1964975805 @default.
• W2060366140 cites W1966009694 @default.
• W2060366140 cites W1970239046 @default.
• W2060366140 cites W1971342115 @default.
• W2060366140 cites W1984207232 @default.
• W2060366140 cites W1984761779 @default.
• W2060366140 cites W1985407614 @default.
• W2060366140 cites W1985516113 @default.
• W2060366140 cites W1988890548 @default.
• W2060366140 cites W1994194230 @default.
• W2060366140 cites W1994267136 @default.
• W2060366140 cites W1999745627 @default.
• W2060366140 cites W2005898886 @default.
• W2060366140 cites W2011891975 @default.
• W2060366140 cites W2014555065 @default.
• W2060366140 cites W2016966383 @default.
• W2060366140 cites W2022686807 @default.
• W2060366140 cites W2026502021 @default.
• W2060366140 cites W2028138888 @default.
• W2060366140 cites W2037086729 @default.
• W2060366140 cites W2038270465 @default.
• W2060366140 cites W2040174416 @default.
• W2060366140 cites W2044618657 @default.
• W2060366140 cites W2045488135 @default.
• W2060366140 cites W2048182307 @default.
• W2060366140 cites W2051176079 @default.
• W2060366140 cites W2059951482 @default.
• W2060366140 cites W2068033906 @default.
• W2060366140 cites W2069417551 @default.
• W2060366140 cites W2075248695 @default.
• W2060366140 cites W2075788671 @default.
• W2060366140 cites W2076295492 @default.
• W2060366140 cites W2078027978 @default.
• W2060366140 cites W2080487390 @default.
• W2060366140 cites W2083221557 @default.
• W2060366140 cites W2085272710 @default.
• W2060366140 cites W2090145179 @default.
• W2060366140 cites W2131289400 @default.
• W2060366140 cites W2149564822 @default.
• W2060366140 cites W2154181324 @default.
• W2060366140 cites W2159450460 @default.
• W2060366140 cites W2161580101 @default.
• W2060366140 cites W2161591591 @default.
• W2060366140 cites W2170811544 @default.
• W2060366140 cites W2278120109 @default.
• W2060366140 cites W4249487565 @default.
• W2060366140 cites W4297820747 @default.
• W2060366140 cites W50896875 @default.
• W2060366140 cites W99970865 @default.
• W2060366140 doi "https://doi.org/10.1208/s12248-011-9309-2" @default.
• W2060366140 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3291190" @default.
• W2060366140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22173945" @default.
• W2060366140 hasPublicationYear "2011" @default.
• W2060366140 type Work @default.
• W2060366140 sameAs 2060366140 @default.
• W2060366140 citedByCount "20" @default.
• W2060366140 countsByYear W20603661402012 @default.
• W2060366140 countsByYear W20603661402013 @default.
• W2060366140 countsByYear W20603661402014 @default.
• W2060366140 countsByYear W20603661402015 @default.
• W2060366140 countsByYear W20603661402017 @default.
• W2060366140 countsByYear W20603661402018 @default.
• W2060366140 countsByYear W20603661402021 @default.
• W2060366140 countsByYear W20603661402023 @default.
• W2060366140 crossrefType "journal-article" @default.
• W2060366140 hasAuthorship W2060366140A5036587808 @default.
• W2060366140 hasAuthorship W2060366140A5058107595 @default.
• W2060366140 hasAuthorship W2060366140A5069387057 @default.
• W2060366140 hasAuthorship W2060366140A5070477947 @default.
• W2060366140 hasAuthorship W2060366140A5086461352 @default.
• W2060366140 hasBestOaLocation W20603661402 @default.
• W2060366140 hasConcept C10138342 @default.
• W2060366140 hasConcept C112705442 @default.
• W2060366140 hasConcept C126322002 @default.
• W2060366140 hasConcept C150903083 @default.
• W2060366140 hasConcept C159654299 @default.
• W2060366140 hasConcept C162324750 @default.
• W2060366140 hasConcept C185592680 @default.

• next