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- W2060366910 abstract "In order, to determine if one eye could serve as control for the other, the variation of choline acetyltransferase in the two eyes of rabbits, cats, cattle and humans was investigated. The enzyme activities of the two corneas, irides, ciliary bodies, retinas and pigment epithelium-choroids of each species varied, on the average, by less than 20% with these exceptions: human corneas (35%), feline ciliary bodies (24%), bovine ciliary bodies (49%), feline retinas (44%), bovine retinas (28)% and rabbit pigment epithelium-choroids (39%). Ocular choline acetyltransferase activity has been shown to vary markedly within a given species, e.g., the corneal activity of one rabbit could be 50 times that of another rabbit. When the enzyme activities of littermates and highly inbred rabbits were compared to those from randomly bred animals, the data suggested that ocular choline acetyltransferase activity was partially under genetic control. Highly inbred rabbits (F = 82–85%) exhibited significantly less variation (P < 0·005) than randomly chosen rabbits. The location and distribution of corneal epithelium choline acetyltransferase were investigated by performing regional assays and denervation experiments in rabbits. Central cornea had the highest enzyme activity (P < 0·05) and superior and temporal cornea had the least. Denervation by retrobulbar ethanol did not lower corneal choline acetyltransferase activity although that of iris-ciliary body fell 63–91% within one week. It was concluded that corneal choline acetyltransferase resides primarily, or entirely, within the epithelial cells and not in the sensory terminals of the trigeminal nerve." @default.
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- W2060366910 title "Variability of choline acetyltransferase in ocular tissues of rabbits, cats, cattle and humans" @default.
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- W2060366910 doi "https://doi.org/10.1016/0014-4835(77)90281-0" @default.
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