FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060367669> ?p ?o ?g. }

• W2060367669 endingPage "24332" @default.
• W2060367669 startingPage "24321" @default.
• W2060367669 abstract "The synthesis of the <i>Escherichia coli</i>zinc transporter, encoded by the <i>znuACB</i> gene cluster, is regulated in response to the intracellular zinc concentration by the<i>zur</i> gene product. Inactivation of the <i>zur</i> gene demonstrated that Zur acts as a repressor when binding Zn²⁺. Eight chromosomal mutant <i>zur</i> alleles were sequenced to correlate the loss of Zur function with individual mutations. Wild-type Zur and ZurΔ46–91 formed homo- and heterodimers. Dimerization was independent of metal ions since it also occurred in the presence of metal chelators. Using an <i>in vivo</i> titration assay, the <i>znu</i> operator was narrowed down to a 31-base pair region overlapping the translational start site of <i>znuA</i>. This location was confirmed by footprinting assays. Zur directly binds to a single region comprising a nearly perfect palindrome. Zinc chelators completely inhibited and Zn²⁺ in low concentrations enhanced DNA binding of Zur. No evidence for autoregulation of Zur was found. Zur binds at least 2 zinc ions/dimer specifically. Although most of the mutant Zur proteins bound to the <i>znu</i> operator <i>in vitro</i>, no protection was observed in <i>in vivo</i> footprinting experiments. Analysis of the mutant Zur proteins suggested an amino-terminal DNA contact domain around residue 65 and a dimerization and Zn²⁺-binding domain toward the carboxyl-terminal end." @default.
• W2060367669 created "2016-06-24" @default.
• W2060367669 creator A5019488858 @default.
• W2060367669 creator A5066707127 @default.
• W2060367669 date "2000-08-01" @default.
• W2060367669 modified "2023-10-13" @default.
• W2060367669 title "The Zinc-responsive Regulator Zur and Its Control of theznu Gene Cluster Encoding the ZnuABC Zinc Uptake System in Escherichia coli" @default.
• W2060367669 cites W1259363667 @default.
• W2060367669 cites W1596689072 @default.
• W2060367669 cites W1912451872 @default.
• W2060367669 cites W1938326461 @default.
• W2060367669 cites W1965790910 @default.
• W2060367669 cites W1967164846 @default.
• W2060367669 cites W1975329612 @default.
• W2060367669 cites W1975993749 @default.
• W2060367669 cites W1995293508 @default.
• W2060367669 cites W2023853172 @default.
• W2060367669 cites W2027970193 @default.
• W2060367669 cites W2028622989 @default.
• W2060367669 cites W2040350531 @default.
• W2060367669 cites W2042814467 @default.
• W2060367669 cites W2045773639 @default.
• W2060367669 cites W2049297824 @default.
• W2060367669 cites W2051449352 @default.
• W2060367669 cites W2061051066 @default.
• W2060367669 cites W2066907612 @default.
• W2060367669 cites W2068518785 @default.
• W2060367669 cites W2070643079 @default.
• W2060367669 cites W2072333420 @default.
• W2060367669 cites W2072779885 @default.
• W2060367669 cites W2085881545 @default.
• W2060367669 cites W2090811119 @default.
• W2060367669 cites W2100223450 @default.
• W2060367669 cites W2101039716 @default.
• W2060367669 cites W2118242179 @default.
• W2060367669 cites W2123644073 @default.
• W2060367669 cites W2126680603 @default.
• W2060367669 cites W2131282911 @default.
• W2060367669 cites W2134153749 @default.
• W2060367669 cites W2136233218 @default.
• W2060367669 cites W2139802399 @default.
• W2060367669 cites W2141653906 @default.
• W2060367669 cites W2153331635 @default.
• W2060367669 cites W2154936481 @default.
• W2060367669 cites W2155260714 @default.
• W2060367669 cites W2166999322 @default.
• W2060367669 cites W4232534952 @default.
• W2060367669 cites W4293247451 @default.
• W2060367669 cites W4295127969 @default.
• W2060367669 doi "https://doi.org/10.1074/jbc.m001775200" @default.
• W2060367669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10816566" @default.
• W2060367669 hasPublicationYear "2000" @default.
• W2060367669 type Work @default.
• W2060367669 sameAs 2060367669 @default.
• W2060367669 citedByCount "203" @default.
• W2060367669 countsByYear W20603676692012 @default.
• W2060367669 countsByYear W20603676692013 @default.
• W2060367669 countsByYear W20603676692014 @default.
• W2060367669 countsByYear W20603676692015 @default.
• W2060367669 countsByYear W20603676692016 @default.
• W2060367669 countsByYear W20603676692017 @default.
• W2060367669 countsByYear W20603676692018 @default.
• W2060367669 countsByYear W20603676692019 @default.
• W2060367669 countsByYear W20603676692020 @default.
• W2060367669 countsByYear W20603676692021 @default.
• W2060367669 countsByYear W20603676692022 @default.
• W2060367669 countsByYear W20603676692023 @default.
• W2060367669 crossrefType "journal-article" @default.
• W2060367669 hasAuthorship W2060367669A5019488858 @default.
• W2060367669 hasAuthorship W2060367669A5066707127 @default.
• W2060367669 hasBestOaLocation W20603676691 @default.
• W2060367669 hasConcept C101762097 @default.
• W2060367669 hasConcept C104317684 @default.
• W2060367669 hasConcept C107824862 @default.
• W2060367669 hasConcept C143065580 @default.
• W2060367669 hasConcept C150194340 @default.
• W2060367669 hasConcept C153911025 @default.
• W2060367669 hasConcept C158448853 @default.
• W2060367669 hasConcept C178790620 @default.
• W2060367669 hasConcept C185592680 @default.
• W2060367669 hasConcept C22427896 @default.
• W2060367669 hasConcept C2778021871 @default.
• W2060367669 hasConcept C535196362 @default.
• W2060367669 hasConcept C547475151 @default.
• W2060367669 hasConcept C552990157 @default.
• W2060367669 hasConcept C55493867 @default.
• W2060367669 hasConcept C86339819 @default.
• W2060367669 hasConcept C86803240 @default.
• W2060367669 hasConceptScore W2060367669C101762097 @default.
• W2060367669 hasConceptScore W2060367669C104317684 @default.
• W2060367669 hasConceptScore W2060367669C107824862 @default.
• W2060367669 hasConceptScore W2060367669C143065580 @default.
• W2060367669 hasConceptScore W2060367669C150194340 @default.
• W2060367669 hasConceptScore W2060367669C153911025 @default.
• W2060367669 hasConceptScore W2060367669C158448853 @default.
• W2060367669 hasConceptScore W2060367669C178790620 @default.
• W2060367669 hasConceptScore W2060367669C185592680 @default.
• W2060367669 hasConceptScore W2060367669C22427896 @default.

• next