Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060372016> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2060372016 abstract "Hypoxia-inducible factor-1 (HIF-1) represents an important tumor-selective molecular target for anti-cancer drug discovery. The lipid extract of Lonchocarpus glabrescens (0.5 µg/mL) inhibited hypoxia-induced HIF-1 activation by 90% in a human breast carcinoma T47D cell-based reporter assay. Bioassay-guided isolation and structure elucidation yielded alpinumisoflavone (1, IC50 5µM) and 4ʹ-O-methylalpinumisoflavone (2, IC50 0.6µM), and rotenone (3, IC50 0.001µM). Rotenone (3) selectively suppressed hypoxia-induced HIF-1 activation, relative to its effect on iron chelator-induced HIF-1 activation (> 100 fold selectivity). Both 2 and 3 inhibited the hypoxic induction of HIF-1 target genes (CDKN1A, GLUT-1, and VEGF) in T47D cells. Compounds 1 and 2 suppressed tumor cell migration in a MDA-MB-231 cell-based migration assay, while 3 had no effect. Both 2 and 3 inhibited hypoxic induction of HIF-1α protein, the oxygen regulated subunit that determines HIF-1 activity. Mechanism studies indicate that 3 inhibits HIF-1 activity by suppressing mitochondrial respiration, while 2 simultaneously suppresses mitochondrial respiration and disrupts protein translation in vitro. 1 R = H 2 R = CH3" @default.
- W2060372016 created "2016-06-24" @default.
- W2060372016 creator A5050419727 @default.
- W2060372016 date "2008-02-01" @default.
- W2060372016 modified "2023-09-25" @default.
- W2060372016 title "Alpinum isoflavone, Methylalpinum isoflavone and Rotenone – Lonchocarpus glabrescens Metabolites that Inhibit HIF-1 Activation and Tumor Cell Migration" @default.
- W2060372016 doi "https://doi.org/10.1055/s-2008-1075192" @default.
- W2060372016 hasPublicationYear "2008" @default.
- W2060372016 type Work @default.
- W2060372016 sameAs 2060372016 @default.
- W2060372016 citedByCount "1" @default.
- W2060372016 countsByYear W20603720162019 @default.
- W2060372016 crossrefType "journal-article" @default.
- W2060372016 hasAuthorship W2060372016A5050419727 @default.
- W2060372016 hasConcept C104317684 @default.
- W2060372016 hasConcept C1491633281 @default.
- W2060372016 hasConcept C153911025 @default.
- W2060372016 hasConcept C160450060 @default.
- W2060372016 hasConcept C178790620 @default.
- W2060372016 hasConcept C182215343 @default.
- W2060372016 hasConcept C185592680 @default.
- W2060372016 hasConcept C202751555 @default.
- W2060372016 hasConcept C2225953 @default.
- W2060372016 hasConcept C2777752497 @default.
- W2060372016 hasConcept C2778389096 @default.
- W2060372016 hasConcept C28859421 @default.
- W2060372016 hasConcept C540031477 @default.
- W2060372016 hasConcept C54355233 @default.
- W2060372016 hasConcept C55493867 @default.
- W2060372016 hasConcept C59822182 @default.
- W2060372016 hasConcept C7836513 @default.
- W2060372016 hasConcept C81885089 @default.
- W2060372016 hasConcept C86803240 @default.
- W2060372016 hasConceptScore W2060372016C104317684 @default.
- W2060372016 hasConceptScore W2060372016C1491633281 @default.
- W2060372016 hasConceptScore W2060372016C153911025 @default.
- W2060372016 hasConceptScore W2060372016C160450060 @default.
- W2060372016 hasConceptScore W2060372016C178790620 @default.
- W2060372016 hasConceptScore W2060372016C182215343 @default.
- W2060372016 hasConceptScore W2060372016C185592680 @default.
- W2060372016 hasConceptScore W2060372016C202751555 @default.
- W2060372016 hasConceptScore W2060372016C2225953 @default.
- W2060372016 hasConceptScore W2060372016C2777752497 @default.
- W2060372016 hasConceptScore W2060372016C2778389096 @default.
- W2060372016 hasConceptScore W2060372016C28859421 @default.
- W2060372016 hasConceptScore W2060372016C540031477 @default.
- W2060372016 hasConceptScore W2060372016C54355233 @default.
- W2060372016 hasConceptScore W2060372016C55493867 @default.
- W2060372016 hasConceptScore W2060372016C59822182 @default.
- W2060372016 hasConceptScore W2060372016C7836513 @default.
- W2060372016 hasConceptScore W2060372016C81885089 @default.
- W2060372016 hasConceptScore W2060372016C86803240 @default.
- W2060372016 hasIssue "03" @default.
- W2060372016 hasLocation W20603720161 @default.
- W2060372016 hasOpenAccess W2060372016 @default.
- W2060372016 hasPrimaryLocation W20603720161 @default.
- W2060372016 hasRelatedWork W1984474672 @default.
- W2060372016 hasRelatedWork W2003425030 @default.
- W2060372016 hasRelatedWork W2007171210 @default.
- W2060372016 hasRelatedWork W2023783781 @default.
- W2060372016 hasRelatedWork W2074527668 @default.
- W2060372016 hasRelatedWork W2112944877 @default.
- W2060372016 hasRelatedWork W2409736506 @default.
- W2060372016 hasRelatedWork W2510595495 @default.
- W2060372016 hasRelatedWork W2732535950 @default.
- W2060372016 hasRelatedWork W2012230577 @default.
- W2060372016 hasVolume "74" @default.
- W2060372016 isParatext "false" @default.
- W2060372016 isRetracted "false" @default.
- W2060372016 magId "2060372016" @default.
- W2060372016 workType "article" @default.