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• W2060392967 abstract "Although there are several excellent indexes of myocardial contractility, they require accurate measurement of pressure via left ventricular (LV) catheterization. Here we validate a novel noninvasive contractility index that is dependent only on lumen and wall volume of the LV chamber in patients with normal and compromised LV ejection fraction (LVEF). By analysis of the myocardial chamber as a thick-walled sphere, LV contractility index can be expressed as maximum rate of change of pressure-normalized stress (dσ*/d t max , where σ* = σ/P and σ and P are circumferential stress and pressure, respectively). To validate this parameter, dσ*/d t max was determined from contrast cine-ventriculography-assessed LV cavity and myocardial volumes and compared with LVEF, dP/d t max , maximum active elastance ( E a,max ), and single-beat end-systolic elastance [ E es(SB) ] in 30 patients undergoing clinically indicated LV catheterization. Patients with different tertiles of LVEF exhibit statistically significant differences in dσ*/d t max . There was a significant correlation between dσ*/d t max and dP/d t max (dσ*/d t max = 0.0075dP/d t max − 4.70, r = 0.88, P < 0.01), E a,max (dσ*/d t max = 1.20 E a,max + 1.40, r = 0.89, P < 0.01), and E es(SB) [dσ*/d t max = 1.60 E es(SB) + 1.20, r = 0.88, P < 0.01]. In 30 additional individuals, we determined sensitivity of the parameter to changes in preload (intravenous saline infusion, n = 10 subjects), afterload (sublingual glyceryl trinitrate, n = 10 subjects), and increased contractility (intravenous dobutamine, n = 10 patients). We confirmed that the index is not dependent on load but is sensitive to changes in contractility. In conclusion, dσ*/d t max is equivalent to dP/d t max , E a,max , and E es(SB) as an index of myocardial contractility and appears to be load independent. In contrast to other measures of contractility, dσ*/d t max can be assessed with noninvasive cardiac imaging and, thereby, should have more routine clinical applicability." @default.
• W2060392967 created "2016-06-24" @default.
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• W2060392967 date "2007-06-01" @default.
• W2060392967 modified "2023-10-14" @default.
• W2060392967 title "Validation of a novel noninvasive cardiac index of left ventricular contractility in patients" @default.
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• W2060392967 doi "https://doi.org/10.1152/ajpheart.00540.2006" @default.
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