FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060393956> ?p ?o ?g. }

• W2060393956 endingPage "31" @default.
• W2060393956 startingPage "19" @default.
• W2060393956 abstract "The mechanism of metabolic injury induced by the chemical warfare agent sulfur mustard (2,2'-dichlorodiethyl sulfide, HD) was examined in cultured human epidermal keratinocytes (HEK). Although the cell viability and oxidized nicotinamide-adenine dinucleotide phosphate (NADP + ) levels were maintained for 8 h after exposure to 0.33 mM HD, glucose utilization and lactate production were inhibited by 50%. The oxidized nicotinamide-adenine dinucleotide (NAD + ) content decreased linearly during the initial 3 to 4 h, leveling off to between 50 and 60% of control values for ≤8 h. Exposure to HD at 0.07 mM HD caused a time-dependent decrease in these same parameters. At 0 to 8 h after exposure, concentrations of HD between 0.03 and 0.17 mM caused increased rates of glycolysis in half of the experiments, thus suggesting activation of energy-requiring repair pathways. These results demonstrate that depletion of NAD + and inhibition of glucose metabolism are a function of HD dose and postexposure time. NAD + depletion and inhibition of glucose metabolism preceded the loss of cell viability as determined by dye exclusion. The various end points measured showed similar, but not necessarily identical, responses to the dose of HD and the time after exposure. HD also induced shifts in the cellular metabolic patterns; this suggests that the alterations in glucose metabolism were not simply a function of NAD + depletion. The data are consistent with the conclusion that HEK metabolize glucose primarily via anaerobic glycolysis and that HD induces complex shifts in the patterns of metabolic activity. We conclude that the relationships between HD exposure, intarcellular NAD + , and the rates of glucose metabolism are more complex than originally proposed." @default.
• W2060393956 created "2016-06-24" @default.
• W2060393956 creator A5001043449 @default.
• W2060393956 date "1996-01-01" @default.
• W2060393956 modified "2023-10-14" @default.
• W2060393956 title "In Vitro Studies of Glucose Metabolism in Human Epidermal Keratinocytes Exposed to Sulfur Mustard" @default.
• W2060393956 cites W140773193 @default.
• W2060393956 cites W1566830427 @default.
• W2060393956 cites W1964871000 @default.
• W2060393956 cites W1985504590 @default.
• W2060393956 cites W1991179544 @default.
• W2060393956 cites W1996031212 @default.
• W2060393956 cites W1998580847 @default.
• W2060393956 cites W2015206944 @default.
• W2060393956 cites W2018275178 @default.
• W2060393956 cites W2038234449 @default.
• W2060393956 cites W2050325215 @default.
• W2060393956 cites W2075109532 @default.
• W2060393956 cites W2078260061 @default.
• W2060393956 cites W2085789090 @default.
• W2060393956 cites W2099342380 @default.
• W2060393956 cites W3097326077 @default.
• W2060393956 cites W3183549417 @default.
• W2060393956 cites W3215619572 @default.
• W2060393956 cites W83000222 @default.
• W2060393956 doi "https://doi.org/10.3109/10915819609048334" @default.
• W2060393956 hasPublicationYear "1996" @default.
• W2060393956 type Work @default.
• W2060393956 sameAs 2060393956 @default.
• W2060393956 citedByCount "6" @default.
• W2060393956 countsByYear W20603939562020 @default.
• W2060393956 crossrefType "journal-article" @default.
• W2060393956 hasAuthorship W2060393956A5001043449 @default.
• W2060393956 hasConcept C17093226 @default.
• W2060393956 hasConcept C178790620 @default.
• W2060393956 hasConcept C185592680 @default.
• W2060393956 hasConcept C202751555 @default.
• W2060393956 hasConcept C2777459323 @default.
• W2060393956 hasConcept C2780644109 @default.
• W2060393956 hasConcept C29730261 @default.
• W2060393956 hasConcept C33070731 @default.
• W2060393956 hasConcept C54355233 @default.
• W2060393956 hasConcept C55493867 @default.
• W2060393956 hasConcept C62231903 @default.
• W2060393956 hasConcept C86803240 @default.
• W2060393956 hasConcept C98274493 @default.
• W2060393956 hasConceptScore W2060393956C17093226 @default.
• W2060393956 hasConceptScore W2060393956C178790620 @default.
• W2060393956 hasConceptScore W2060393956C185592680 @default.
• W2060393956 hasConceptScore W2060393956C202751555 @default.
• W2060393956 hasConceptScore W2060393956C2777459323 @default.
• W2060393956 hasConceptScore W2060393956C2780644109 @default.
• W2060393956 hasConceptScore W2060393956C29730261 @default.
• W2060393956 hasConceptScore W2060393956C33070731 @default.
• W2060393956 hasConceptScore W2060393956C54355233 @default.
• W2060393956 hasConceptScore W2060393956C55493867 @default.
• W2060393956 hasConceptScore W2060393956C62231903 @default.
• W2060393956 hasConceptScore W2060393956C86803240 @default.
• W2060393956 hasConceptScore W2060393956C98274493 @default.
• W2060393956 hasLocation W20603939561 @default.
• W2060393956 hasOpenAccess W2060393956 @default.
• W2060393956 hasPrimaryLocation W20603939561 @default.
• W2060393956 hasRelatedWork W1507928471 @default.
• W2060393956 hasRelatedWork W1565199071 @default.
• W2060393956 hasRelatedWork W2035870153 @default.
• W2060393956 hasRelatedWork W2048434799 @default.
• W2060393956 hasRelatedWork W2151261978 @default.
• W2060393956 hasRelatedWork W2416093955 @default.
• W2060393956 hasRelatedWork W2593444473 @default.
• W2060393956 hasRelatedWork W2724877293 @default.
• W2060393956 hasRelatedWork W624631823 @default.
• W2060393956 hasRelatedWork W2164705707 @default.
• W2060393956 hasVolume "15" @default.
• W2060393956 isParatext "false" @default.
• W2060393956 isRetracted "false" @default.
• W2060393956 magId "2060393956" @default.
• W2060393956 workType "article" @default.