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- W2060396345 abstract "Angiotensin II (Ang II) is the main active peptide of the renin–angiotensin system (RAS), producing a number of inflammatory mediators that lead to endothelial dysfunction and the progression of atherosclerosis. Ang II-induced NF-κB nuclear translocation plays a pivotal role in this response. This study examines the NF-κB activation mechanism elicited by Ang II in human umbilical vein endothelial cells (HUVEC). Electrophoretic mobility shift assays and Western blotting revealed that Ang II, signaling via AT1, produces a time-dependent increase in NF-κB DNA binding and IκBα degradation. These results also demonstrate that Ang II leads to MAPK phosphorylation and p38MAPK pathway-induced NF-κB activation. Furthermore, AT1 is required for p38MAPK phosphorylation induced by Ang II. This study provides evidence that Ang II elicits NF-κB activation via the p38MAPK pathway in HUVEC." @default.
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- W2060396345 date "2006-12-01" @default.
- W2060396345 modified "2023-09-25" @default.
- W2060396345 title "Angiotensin II induces NF-κB activation in HUVEC via the p38MAPK pathway" @default.
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- W2060396345 doi "https://doi.org/10.1016/j.peptides.2006.08.014" @default.
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