Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060398431> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2060398431 endingPage "145" @default.
- W2060398431 startingPage "142" @default.
- W2060398431 abstract "Abstract Objectives: A simple, quick and low cost HPLC-UV method for assay of meloxicam in plasma and pharmaceutical dosage forms was developed. Methods: Separation and assay of meloxicam, using a simple reverse phase HPLC-UV method was achieved using an Agilent Zorbax SB C18 column, with methanol and 1% aqueous solution of glacial acetic acid as mobile phase. Elution was performed with composition gradient, meloxicam being detected at 355 nm with a 5 minutes analysis time. The method was tested on human plasma and pharmaceutical dosage forms. Results: The retention time of the meloxicam was 3,7 minutes. Regression analysis showed good linearity, with correlation coefficient R= 0,9997; linear regression equation: y = 206,1x -77,5 over the 20-2000 ng/ml concentration range. Limit of detection was determined to be 5 ng/ml and limit of quantification was set at 15 ng/ml. The recovery of the analyte in human plasma was low: 30,50%, however it was reproducible, with a coefficient of variation of 4,83%. The analysis of the tablets resulted in a 85,82% of meloxicam compared to the declared concentration. Conclusions: The method proposed is quick, simple and adequate for detecting the meloxicam in human plasma. Although the recovery rate was low, it was reproducible, which leads to the fact, that improving extraction procedure can optimize the method." @default.
- W2060398431 created "2016-06-24" @default.
- W2060398431 creator A5017161712 @default.
- W2060398431 creator A5018800505 @default.
- W2060398431 creator A5044162050 @default.
- W2060398431 creator A5084430832 @default.
- W2060398431 date "2014-08-01" @default.
- W2060398431 modified "2023-09-27" @default.
- W2060398431 title "Development of a HPLC-UV method for determination of meloxicam in human plasma and pharmaceutical dosage forms" @default.
- W2060398431 cites W1966159345 @default.
- W2060398431 cites W1975196642 @default.
- W2060398431 cites W1975688460 @default.
- W2060398431 cites W1985421829 @default.
- W2060398431 cites W1996280151 @default.
- W2060398431 cites W2029010131 @default.
- W2060398431 cites W2032935263 @default.
- W2060398431 cites W2049235283 @default.
- W2060398431 cites W2062543677 @default.
- W2060398431 cites W2156724874 @default.
- W2060398431 cites W2158682017 @default.
- W2060398431 cites W2186982897 @default.
- W2060398431 cites W2264360960 @default.
- W2060398431 doi "https://doi.org/10.2478/amma-2014-0031" @default.
- W2060398431 hasPublicationYear "2014" @default.
- W2060398431 type Work @default.
- W2060398431 sameAs 2060398431 @default.
- W2060398431 citedByCount "4" @default.
- W2060398431 countsByYear W20603984312017 @default.
- W2060398431 countsByYear W20603984312018 @default.
- W2060398431 countsByYear W20603984312020 @default.
- W2060398431 crossrefType "journal-article" @default.
- W2060398431 hasAuthorship W2060398431A5017161712 @default.
- W2060398431 hasAuthorship W2060398431A5018800505 @default.
- W2060398431 hasAuthorship W2060398431A5044162050 @default.
- W2060398431 hasAuthorship W2060398431A5084430832 @default.
- W2060398431 hasBestOaLocation W20603984311 @default.
- W2060398431 hasConcept C10390740 @default.
- W2060398431 hasConcept C119128265 @default.
- W2060398431 hasConcept C179998833 @default.
- W2060398431 hasConcept C185592680 @default.
- W2060398431 hasConcept C2779751750 @default.
- W2060398431 hasConcept C43617362 @default.
- W2060398431 hasConcept C71924100 @default.
- W2060398431 hasConcept C77281830 @default.
- W2060398431 hasConcept C98274493 @default.
- W2060398431 hasConceptScore W2060398431C10390740 @default.
- W2060398431 hasConceptScore W2060398431C119128265 @default.
- W2060398431 hasConceptScore W2060398431C179998833 @default.
- W2060398431 hasConceptScore W2060398431C185592680 @default.
- W2060398431 hasConceptScore W2060398431C2779751750 @default.
- W2060398431 hasConceptScore W2060398431C43617362 @default.
- W2060398431 hasConceptScore W2060398431C71924100 @default.
- W2060398431 hasConceptScore W2060398431C77281830 @default.
- W2060398431 hasConceptScore W2060398431C98274493 @default.
- W2060398431 hasIssue "4" @default.
- W2060398431 hasLocation W20603984311 @default.
- W2060398431 hasOpenAccess W2060398431 @default.
- W2060398431 hasPrimaryLocation W20603984311 @default.
- W2060398431 hasRelatedWork W1913148260 @default.
- W2060398431 hasRelatedWork W1964888264 @default.
- W2060398431 hasRelatedWork W2006820847 @default.
- W2060398431 hasRelatedWork W2022592148 @default.
- W2060398431 hasRelatedWork W2101836819 @default.
- W2060398431 hasRelatedWork W2137297405 @default.
- W2060398431 hasRelatedWork W2154588018 @default.
- W2060398431 hasRelatedWork W2382109194 @default.
- W2060398431 hasRelatedWork W2393257291 @default.
- W2060398431 hasRelatedWork W2601524031 @default.
- W2060398431 hasVolume "60" @default.
- W2060398431 isParatext "false" @default.
- W2060398431 isRetracted "false" @default.
- W2060398431 magId "2060398431" @default.
- W2060398431 workType "article" @default.