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• W2060418696 endingPage "466" @default.
• W2060418696 startingPage "460" @default.
• W2060418696 abstract "To investigate the metabolic and genetic associations of levels of soluble adhesion molecules, plasma levels of soluble E-selectin and vascular cell adhesion molecule-1 were measured in 60 non-insulin-dependent diabetes mellitus (NIDDM) patients, 60 first-degree relatives of NIDDM patients and 60 control subjects, none of whom displayed clinical features of vascular disease. In addition, E-selectin A561C genotype, coding for a serine to arginine change, was determined. E-selectin levels were elevated in the patient group; 57 [52–63] (mean [95 % confidence intervals]) ng/ml, compared with both relatives; 44 [39–50] ng/ml p = 0.001 and controls 39.5 [36–43] ng/ml p = 0.0001. E-selectin levels correlated with triglycerides, tissue-plasminogen activator and plasminogen activator inhibitor-1 activity in all groups. Levels of E-selectin were related to E-selectin genotype, being higher in subjects possessing the arginine allele (51.4 vs 44.5 ng/ml p < 0.05). E-selectin levels were higher in males than females in controls (female 35 [32–39] vs male 45 [40–51] ng/ml p = 0.004), and NIDDM relatives (female 38 [33–44] vs male 52 [45–61] ng/ml p = 0.004) but not in NIDDM patients where levels were similar (female 58 [49–69] vs male 56 [50–62] ng/ml, ns). There was no difference in soluble vascular cell adhesion molecule-1 levels between the three groups (control 640 [598–686] ng/ml, NIDDM relatives 634 [593–678] ng/ml and NIDDM patients 664 [608–725] ng/ml). In controls and patients vascular cell adhesion molecule-1 levels correlated with von Willebrand factor (vWF). The results indicate that levels of E-selectin relate to vascular risk factors in control subjects, NIDDM relatives and NIDDM patients. [Diabetologia (1998) 41: 460–466]" @default.
• W2060418696 created "2016-06-24" @default.
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• W2060418696 date "1998-03-20" @default.
• W2060418696 modified "2023-09-23" @default.
• W2060418696 title "Soluble vascular cell adhesion molecule-1 and E-selectin levels in relation to vascular risk factors and to E-selectin genotype in the first degree relatives of NIDDM patients and in NIDDM patients" @default.
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• W2060418696 doi "https://doi.org/10.1007/s001250050930" @default.
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