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• W2060432846 abstract "Intestinal epithelial cells have been shown to produce IL-1βin vivo.This gene expression is rapid and precedes most determinants of inflammation, suggesting a pivotal role for IL-1β in the early events leading to inflammation. To better understand the mechanisms leading to this IL-1β production, we have developed anin vitromodel system employing a nontransformed intestinal epithelial cell line that does not constitutively express IL-1β. Following detachment, these cells rapidly expressed IL-1β mRNA. This expression was enhanced, but not induced, by LPS. IL-1β protein was detected by immunoprecipitation in the culture medium from passaged IEC-18 but not intracellularly, suggesting an efficient secretion of the molecule following induction. Interestingly, culture supernatants from passaged cells were without IL-1 bioactivity, suggesting the presence of an inhibitor as well. RT-PCR and Western blot analysis showed expression of IL-1RII by IEC-18 following detachment, possibly explaining the observed lack of bioactivity. These results indicate a novel pathway for IL-1β production and suggest that proinflammatory effects of IEC-derived IL-1 may be modulated by the simultaneous production of IL-1 antagonists." @default.
• W2060432846 created "2016-06-24" @default.
• W2060432846 creator A5006741639 @default.
• W2060432846 creator A5071188287 @default.
• W2060432846 date "1999-04-01" @default.
• W2060432846 modified "2023-10-18" @default.
• W2060432846 title "Rapid Expression of IL-1β by Intestinal Epithelial Cellsin Vitro" @default.
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• W2060432846 doi "https://doi.org/10.1006/cimm.1999.1468" @default.
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