FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060447390> ?p ?o ?g. }

• W2060447390 endingPage "1373" @default.
• W2060447390 startingPage "1361" @default.
• W2060447390 abstract "This paper reports the cloning and sequencing of two pro-inflammatory cytokines, interleukin (IL)-1β and IL-8, in haddock (Melanogrammus aeglefinus) by homology cloning. The complete transcript of the haddock IL-1β was sequenced and contained 1043 bp, including a 762 bp open reading frame. The 3′ end of the gene includes a polyadenylation signal 13 bp upstream of the poly(A) tail, along with 10 instability motifs. The predicted protein of 253aa revealed the presence of the IL-1 family signature and the absence of an ICE cut site. The cDNA of the chemokine IL-8 was sequenced in haddock and contained 903 bp of which 306 bp are the open reading frame. Interestingly, the predicted protein sequence of 101aa, contains an ELR motif preceding the CXC signature, common in all vertebrate IL-8 molecules but absent in all teleost genes sequenced to date. The expression of both haddock cytokines was studied in four different tissues: head kidney, spleen, liver and gill. Tissues were obtained from both healthy fish and fish stimulated in vivo with four commercial serotypes of LPS, namely Escherichia coli 026:B6, 055:B5, 0111:B4 and 0127:B8 and PMA. Haddock IL-1β was not constitutively expressed and expression was only observed following stimulation. However, this expression was stimulant dependent and only PMA and LPS 026:B6 induced high levels of expression in the head kidney. The haddock IL-8 gene on the other hand, showed a constitutive expression, that could be up or down-regulated depending on the immunostimulant used, although to a lesser extent than IL-1β." @default.
• W2060447390 created "2016-06-24" @default.
• W2060447390 creator A5017096316 @default.
• W2060447390 creator A5027886208 @default.
• W2060447390 creator A5038092036 @default.
• W2060447390 creator A5039585656 @default.
• W2060447390 date "2007-02-01" @default.
• W2060447390 modified "2023-09-26" @default.
• W2060447390 title "Cloning and expression analysis of two pro-inflammatory cytokines, IL-1β and IL-8, in haddock (Melanogrammus aeglefinus)" @default.
• W2060447390 cites W1484783481 @default.
• W2060447390 cites W1579558830 @default.
• W2060447390 cites W1582081779 @default.
• W2060447390 cites W1969461218 @default.
• W2060447390 cites W1971255888 @default.
• W2060447390 cites W1973269212 @default.
• W2060447390 cites W1975304761 @default.
• W2060447390 cites W1976415203 @default.
• W2060447390 cites W1981755124 @default.
• W2060447390 cites W1984338631 @default.
• W2060447390 cites W1996539617 @default.
• W2060447390 cites W2000890891 @default.
• W2060447390 cites W2003576103 @default.
• W2060447390 cites W2005475669 @default.
• W2060447390 cites W2014587187 @default.
• W2060447390 cites W2023028120 @default.
• W2060447390 cites W2023302839 @default.
• W2060447390 cites W2039516894 @default.
• W2060447390 cites W2041743110 @default.
• W2060447390 cites W2042617388 @default.
• W2060447390 cites W2054803942 @default.
• W2060447390 cites W2055043387 @default.
• W2060447390 cites W2058825091 @default.
• W2060447390 cites W2066569802 @default.
• W2060447390 cites W2069967691 @default.
• W2060447390 cites W2070129412 @default.
• W2060447390 cites W2074822677 @default.
• W2060447390 cites W2078466187 @default.
• W2060447390 cites W2097462819 @default.
• W2060447390 cites W2100492066 @default.
• W2060447390 cites W2103263438 @default.
• W2060447390 cites W2104918497 @default.
• W2060447390 cites W2106882534 @default.
• W2060447390 cites W2114948357 @default.
• W2060447390 cites W2143372911 @default.
• W2060447390 cites W2146396346 @default.
• W2060447390 cites W2153813165 @default.
• W2060447390 cites W2161746138 @default.
• W2060447390 cites W2162760851 @default.
• W2060447390 cites W2181772590 @default.
• W2060447390 cites W2916193864 @default.
• W2060447390 cites W4210987759 @default.
• W2060447390 cites W4254275792 @default.
• W2060447390 cites W98230974 @default.
• W2060447390 doi "https://doi.org/10.1016/j.molimm.2006.05.010" @default.
• W2060447390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16831460" @default.
• W2060447390 hasPublicationYear "2007" @default.
• W2060447390 type Work @default.
• W2060447390 sameAs 2060447390 @default.
• W2060447390 citedByCount "161" @default.
• W2060447390 countsByYear W20604473902012 @default.
• W2060447390 countsByYear W20604473902013 @default.
• W2060447390 countsByYear W20604473902014 @default.
• W2060447390 countsByYear W20604473902015 @default.
• W2060447390 countsByYear W20604473902016 @default.
• W2060447390 countsByYear W20604473902017 @default.
• W2060447390 countsByYear W20604473902018 @default.
• W2060447390 countsByYear W20604473902019 @default.
• W2060447390 countsByYear W20604473902020 @default.
• W2060447390 countsByYear W20604473902021 @default.
• W2060447390 countsByYear W20604473902022 @default.
• W2060447390 countsByYear W20604473902023 @default.
• W2060447390 crossrefType "journal-article" @default.
• W2060447390 hasAuthorship W2060447390A5017096316 @default.
• W2060447390 hasAuthorship W2060447390A5027886208 @default.
• W2060447390 hasAuthorship W2060447390A5038092036 @default.
• W2060447390 hasAuthorship W2060447390A5039585656 @default.
• W2060447390 hasConcept C104317684 @default.
• W2060447390 hasConcept C153911025 @default.
• W2060447390 hasConcept C167625842 @default.
• W2060447390 hasConcept C187882448 @default.
• W2060447390 hasConcept C19924922 @default.
• W2060447390 hasConcept C2777080836 @default.
• W2060447390 hasConcept C2909208804 @default.
• W2060447390 hasConcept C47289529 @default.
• W2060447390 hasConcept C505870484 @default.
• W2060447390 hasConcept C54355233 @default.
• W2060447390 hasConcept C86803240 @default.
• W2060447390 hasConceptScore W2060447390C104317684 @default.
• W2060447390 hasConceptScore W2060447390C153911025 @default.
• W2060447390 hasConceptScore W2060447390C167625842 @default.
• W2060447390 hasConceptScore W2060447390C187882448 @default.
• W2060447390 hasConceptScore W2060447390C19924922 @default.
• W2060447390 hasConceptScore W2060447390C2777080836 @default.
• W2060447390 hasConceptScore W2060447390C2909208804 @default.
• W2060447390 hasConceptScore W2060447390C47289529 @default.
• W2060447390 hasConceptScore W2060447390C505870484 @default.
• W2060447390 hasConceptScore W2060447390C54355233 @default.
• W2060447390 hasConceptScore W2060447390C86803240 @default.

• next