FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060453982> ?p ?o ?g. }

• W2060453982 endingPage "15" @default.
• W2060453982 startingPage "15" @default.
• W2060453982 abstract "Cordyceps cicadae is a medicinal fungus that is often used for treating cancer. However, the anticancer mechanisms of C. cicadae are largely unknown. This study aims to investigate the anticancer mechanisms of C. cicadae against hepatocellular carcinoma cells in vitro using a proteomic approach. Human hepatocellular carcinoma MHCC97H cells were treated with a water extract of C. cicadae (0, 100, 250, 500, and 1000 μg/mL) for 48 h and harvested for cell viability assays. The significant differences in protein expression between control and C. cicadae-treated cells were analyzed by two-dimensional gel-based proteomics coupled with matrix-assisted laser desorption ionization-time of flight mass spectrometry. Flow cytometry analysis was employed to investigate the cell cycle and cell death. The anticancer molecular mechanism was analyzed by whole proteome mapping. The water extract of C. cicadae (0, 100, 250, 500, and 1000 μg/mL) inhibited the growth of MHCC97H cells in a dose-dependent manner via G2/M phase cell cycle arrest with no evidence of apoptosis. Among the identified proteins with upregulated expression were dynactin subunit 2, N-myc downstream-regulated gene 1, heat shock protein beta-1, alpha-enolase isoform 1, phosphatidylinositol transfer protein, and WD repeat-containing protein 1. Meanwhile, the proteins with downregulated expression were 14-3-3 gamma, BUB3, microtubule-associated protein RP/EB family member 1, thioredoxin-like protein, chloride intracellular channel protein 1, ectonucleoside triphosphate diphosphohydrolase 5, xaa-Pro dipeptidase, enoyl-CoA delta isomerase 1, protein-disulfide isomerase-related chaperone Erp29, hnRNP 2H9B, peroxiredoxin 1, WD-40 repeat protein, and serine/threonine kinase receptor-associated protein. The water extract of C. cicadae reduced the growth of human hepatocellular carcinoma MHCC97H cells via G2/M cell cycle arrest." @default.
• W2060453982 created "2016-06-24" @default.
• W2060453982 creator A5018167422 @default.
• W2060453982 creator A5018872953 @default.
• W2060453982 creator A5029451343 @default.
• W2060453982 creator A5053919156 @default.
• W2060453982 creator A5059458258 @default.
• W2060453982 date "2014-01-01" @default.
• W2060453982 modified "2023-10-06" @default.
• W2060453982 title "Cordyceps cicadae induces G2/M cell cycle arrest in MHCC97H human hepatocellular carcinoma cells: a proteomic study" @default.
• W2060453982 cites W1518838936 @default.
• W2060453982 cites W1965475092 @default.
• W2060453982 cites W1966031767 @default.
• W2060453982 cites W1971588980 @default.
• W2060453982 cites W1974425134 @default.
• W2060453982 cites W1979728345 @default.
• W2060453982 cites W1979857764 @default.
• W2060453982 cites W1980625913 @default.
• W2060453982 cites W1981616764 @default.
• W2060453982 cites W1984174151 @default.
• W2060453982 cites W1984283958 @default.
• W2060453982 cites W1986470198 @default.
• W2060453982 cites W1989254646 @default.
• W2060453982 cites W1993395666 @default.
• W2060453982 cites W1997936048 @default.
• W2060453982 cites W2004407038 @default.
• W2060453982 cites W2017743102 @default.
• W2060453982 cites W2018651892 @default.
• W2060453982 cites W2020316460 @default.
• W2060453982 cites W2038236142 @default.
• W2060453982 cites W2053223779 @default.
• W2060453982 cites W2057363442 @default.
• W2060453982 cites W2057544210 @default.
• W2060453982 cites W2065688435 @default.
• W2060453982 cites W2070000588 @default.
• W2060453982 cites W2071917017 @default.
• W2060453982 cites W2074164438 @default.
• W2060453982 cites W2077778039 @default.
• W2060453982 cites W2087809601 @default.
• W2060453982 cites W2096352820 @default.
• W2060453982 cites W2112655704 @default.
• W2060453982 cites W2114252625 @default.
• W2060453982 cites W2115287848 @default.
• W2060453982 cites W2118132761 @default.
• W2060453982 cites W2125117240 @default.
• W2060453982 cites W2130589938 @default.
• W2060453982 cites W2130819897 @default.
• W2060453982 cites W2135671965 @default.
• W2060453982 cites W2138373786 @default.
• W2060453982 cites W2143422202 @default.
• W2060453982 cites W2144567398 @default.
• W2060453982 cites W2145843377 @default.
• W2060453982 cites W2146171639 @default.
• W2060453982 cites W2154012410 @default.
• W2060453982 cites W2154993590 @default.
• W2060453982 cites W2163949700 @default.
• W2060453982 cites W2168189152 @default.
• W2060453982 cites W2168818408 @default.
• W2060453982 cites W2169403465 @default.
• W2060453982 cites W2170304997 @default.
• W2060453982 cites W2171212437 @default.
• W2060453982 cites W2328309533 @default.
• W2060453982 doi "https://doi.org/10.1186/1749-8546-9-15" @default.
• W2060453982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4036300" @default.
• W2060453982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24872842" @default.
• W2060453982 hasPublicationYear "2014" @default.
• W2060453982 type Work @default.
• W2060453982 sameAs 2060453982 @default.
• W2060453982 citedByCount "19" @default.
• W2060453982 countsByYear W20604539822015 @default.
• W2060453982 countsByYear W20604539822016 @default.
• W2060453982 countsByYear W20604539822017 @default.
• W2060453982 countsByYear W20604539822018 @default.
• W2060453982 countsByYear W20604539822019 @default.
• W2060453982 countsByYear W20604539822020 @default.
• W2060453982 countsByYear W20604539822021 @default.
• W2060453982 countsByYear W20604539822022 @default.
• W2060453982 countsByYear W20604539822023 @default.
• W2060453982 crossrefType "journal-article" @default.
• W2060453982 hasAuthorship W2060453982A5018167422 @default.
• W2060453982 hasAuthorship W2060453982A5018872953 @default.
• W2060453982 hasAuthorship W2060453982A5029451343 @default.
• W2060453982 hasAuthorship W2060453982A5053919156 @default.
• W2060453982 hasAuthorship W2060453982A5059458258 @default.
• W2060453982 hasBestOaLocation W20604539821 @default.
• W2060453982 hasConcept C104317684 @default.
• W2060453982 hasConcept C104397665 @default.
• W2060453982 hasConcept C105696609 @default.
• W2060453982 hasConcept C153911025 @default.
• W2060453982 hasConcept C158617107 @default.
• W2060453982 hasConcept C185592680 @default.
• W2060453982 hasConcept C190283241 @default.
• W2060453982 hasConcept C29537977 @default.
• W2060453982 hasConcept C46111723 @default.
• W2060453982 hasConcept C5098756 @default.
• W2060453982 hasConcept C55493867 @default.
• W2060453982 hasConcept C86803240 @default.
• W2060453982 hasConcept C95444343 @default.

• next