Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060485896> ?p ?o ?g. }
- W2060485896 endingPage "241" @default.
- W2060485896 startingPage "234" @default.
- W2060485896 abstract "There is considerable evidence that drug reward and brain stimulation reward (BSR) share common neural substrates. Although it is known that exposure to drugs of abuse causes a variety of molecular changes in brain reward systems, little is known about the molecular consequences of BSR. We report that repeated exposure to rewarding stimulation of the medial forebrain bundle (MFB) selectively decreases expression of GluR1 (an AMPA receptor subunit) in the VTA, without effect on expression of several other proteins (GluR2, NMDAR1, tyrosine hydroxylase). This effect of BSR on GluR1 expression is opposite of that caused by intermittent exposure to cocaine and morphine, which are known to elevate GluR1 expression in the VTA. Considering that elevated GluR1 expression in the VTA has been associated with increased sensitivity to drug reward, the finding that BSR and drugs of abuse have opposite effects on GluR1 expression in this region may provide an explanation for why the reward-related effects of many drugs (cocaine, morphine, amphetamine, PCP, nicotine) do not sensitize with repeated testing in BSR procedures that quantify reward strength." @default.
- W2060485896 created "2016-06-24" @default.
- W2060485896 creator A5003670280 @default.
- W2060485896 creator A5005817928 @default.
- W2060485896 creator A5012233991 @default.
- W2060485896 creator A5014532060 @default.
- W2060485896 creator A5024383091 @default.
- W2060485896 creator A5055552050 @default.
- W2060485896 creator A5006396816 @default.
- W2060485896 date "2001-08-01" @default.
- W2060485896 modified "2023-10-10" @default.
- W2060485896 title "Repeated Exposure to Rewarding Brain Stimulation Downregulates GluR1 Expression in the Ventral Tegmental Area" @default.
- W2060485896 cites W1487599137 @default.
- W2060485896 cites W1562307516 @default.
- W2060485896 cites W1662277789 @default.
- W2060485896 cites W1775749144 @default.
- W2060485896 cites W1781339509 @default.
- W2060485896 cites W1980425974 @default.
- W2060485896 cites W1983546713 @default.
- W2060485896 cites W1984777669 @default.
- W2060485896 cites W1988659186 @default.
- W2060485896 cites W1989794730 @default.
- W2060485896 cites W1991829536 @default.
- W2060485896 cites W2005657014 @default.
- W2060485896 cites W2008526948 @default.
- W2060485896 cites W2009065642 @default.
- W2060485896 cites W2009243814 @default.
- W2060485896 cites W2012443067 @default.
- W2060485896 cites W2015011123 @default.
- W2060485896 cites W2015894122 @default.
- W2060485896 cites W2016713233 @default.
- W2060485896 cites W2017277436 @default.
- W2060485896 cites W2020710396 @default.
- W2060485896 cites W2023877903 @default.
- W2060485896 cites W2026721213 @default.
- W2060485896 cites W2029503737 @default.
- W2060485896 cites W2031101928 @default.
- W2060485896 cites W2032266578 @default.
- W2060485896 cites W2035501622 @default.
- W2060485896 cites W2045447561 @default.
- W2060485896 cites W2053173480 @default.
- W2060485896 cites W2077655894 @default.
- W2060485896 cites W2080778713 @default.
- W2060485896 cites W2081041064 @default.
- W2060485896 cites W2094458713 @default.
- W2060485896 cites W2097249485 @default.
- W2060485896 cites W2101658107 @default.
- W2060485896 cites W2106862702 @default.
- W2060485896 cites W2108100480 @default.
- W2060485896 cites W2129108032 @default.
- W2060485896 cites W2163815564 @default.
- W2060485896 cites W2264979256 @default.
- W2060485896 cites W2292444051 @default.
- W2060485896 doi "https://doi.org/10.1016/s0893-133x(01)00232-9" @default.
- W2060485896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11425507" @default.
- W2060485896 hasPublicationYear "2001" @default.
- W2060485896 type Work @default.
- W2060485896 sameAs 2060485896 @default.
- W2060485896 citedByCount "39" @default.
- W2060485896 countsByYear W20604858962012 @default.
- W2060485896 countsByYear W20604858962013 @default.
- W2060485896 countsByYear W20604858962014 @default.
- W2060485896 countsByYear W20604858962015 @default.
- W2060485896 countsByYear W20604858962016 @default.
- W2060485896 countsByYear W20604858962017 @default.
- W2060485896 countsByYear W20604858962018 @default.
- W2060485896 countsByYear W20604858962020 @default.
- W2060485896 countsByYear W20604858962022 @default.
- W2060485896 crossrefType "journal-article" @default.
- W2060485896 hasAuthorship W2060485896A5003670280 @default.
- W2060485896 hasAuthorship W2060485896A5005817928 @default.
- W2060485896 hasAuthorship W2060485896A5006396816 @default.
- W2060485896 hasAuthorship W2060485896A5012233991 @default.
- W2060485896 hasAuthorship W2060485896A5014532060 @default.
- W2060485896 hasAuthorship W2060485896A5024383091 @default.
- W2060485896 hasAuthorship W2060485896A5055552050 @default.
- W2060485896 hasBestOaLocation W20604858961 @default.
- W2060485896 hasConcept C126322002 @default.
- W2060485896 hasConcept C137183658 @default.
- W2060485896 hasConcept C143661069 @default.
- W2060485896 hasConcept C15744967 @default.
- W2060485896 hasConcept C159167319 @default.
- W2060485896 hasConcept C160268369 @default.
- W2060485896 hasConcept C169760540 @default.
- W2060485896 hasConcept C170493617 @default.
- W2060485896 hasConcept C24998067 @default.
- W2060485896 hasConcept C2776552330 @default.
- W2060485896 hasConcept C2776669363 @default.
- W2060485896 hasConcept C2777193897 @default.
- W2060485896 hasConcept C2777389121 @default.
- W2060485896 hasConcept C2778941446 @default.
- W2060485896 hasConcept C2779547902 @default.
- W2060485896 hasConcept C2779715522 @default.
- W2060485896 hasConcept C2780948874 @default.
- W2060485896 hasConcept C48856860 @default.
- W2060485896 hasConcept C513476851 @default.
- W2060485896 hasConcept C529278444 @default.
- W2060485896 hasConcept C61174792 @default.