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- W2060488877 abstract "The F1 hybrid of New Zealand black and New Zealand white mice--the NZB/W mouse--spontaneously develops a disease similar to human systemic lupus erythematosus. Male NZB/W mice with established disease were treated with a stable derivative of prostaglandin E1, 15(S)-15 methyl PGE1 (4 micrograms twice daily) from 7 months of age. The pge analog prolonged survival of these mice: At 14 months 7 of 10 control mice had died, whereas 9 of 10 15(S)-15 methyl PGE1 treated mice remained alive. Thus a dose of 200 micrograms/Kg/day 14(S)-15 methyl PGE1 retards progression of murine lupus." @default.
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- W2060488877 modified "2023-09-26" @default.
- W2060488877 title "Treatment of NZB/W (“lupus”) mice with 15(S)-15 methyl PGE1" @default.
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- W2060488877 doi "https://doi.org/10.1016/0161-4630(80)90023-3" @default.
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