Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060496135> ?p ?o ?g. }
- W2060496135 endingPage "1950" @default.
- W2060496135 startingPage "1939" @default.
- W2060496135 abstract "Abstract The establishment of transcriptional silencing in yeast requires cell-cycle progression, but the nature of this requirement is unknown. Sir2 is a protein deacetylase that is required for gene silencing in yeast. We have used temperature-sensitive alleles of the SIR2 gene to assess Sir2's contribution to silencing as a function of the cell cycle. When examined in vivo, these conditional alleles fall into two classes: one class exhibits a loss of silencing when raised to the nonpermissive temperature regardless of cell-cycle position, while the second class exhibits a mitosis-specific silencing defect. Alleles of the first class have a primary defect in protein deacetylase activity, while the alleles of the second class are specifically defective in Sir2–Sir4 interactions at nonpermissive temperatures. Using a SIR2 temperature-sensitive allele, we show that silencing can be established at the HML locus during progression through the G2/M–G1 interval. These results suggest that yeast heterochromatin undergoes structural transitions as a function of the cell cycle and support the existence of a critical assembly step for silent chromatin in mitosis." @default.
- W2060496135 created "2016-06-24" @default.
- W2060496135 creator A5011792309 @default.
- W2060496135 creator A5029881305 @default.
- W2060496135 creator A5045443541 @default.
- W2060496135 creator A5059987707 @default.
- W2060496135 creator A5070558214 @default.
- W2060496135 creator A5071827654 @default.
- W2060496135 date "2006-08-01" @default.
- W2060496135 modified "2023-09-24" @default.
- W2060496135 title "New Alleles of <i>SIR2</i> Define Cell-Cycle-Specific Silencing Functions" @default.
- W2060496135 cites W137594337 @default.
- W2060496135 cites W1575542444 @default.
- W2060496135 cites W1658331573 @default.
- W2060496135 cites W1877035800 @default.
- W2060496135 cites W1903792504 @default.
- W2060496135 cites W1968002116 @default.
- W2060496135 cites W1974890383 @default.
- W2060496135 cites W1975593876 @default.
- W2060496135 cites W1975685790 @default.
- W2060496135 cites W1994900084 @default.
- W2060496135 cites W1995111407 @default.
- W2060496135 cites W1997859335 @default.
- W2060496135 cites W2003312750 @default.
- W2060496135 cites W2006901859 @default.
- W2060496135 cites W2008187459 @default.
- W2060496135 cites W2015669100 @default.
- W2060496135 cites W2017525855 @default.
- W2060496135 cites W2019790163 @default.
- W2060496135 cites W2021309301 @default.
- W2060496135 cites W2032953472 @default.
- W2060496135 cites W2037104460 @default.
- W2060496135 cites W2041959419 @default.
- W2060496135 cites W2042960789 @default.
- W2060496135 cites W2048500913 @default.
- W2060496135 cites W2049094938 @default.
- W2060496135 cites W2053397454 @default.
- W2060496135 cites W2053743856 @default.
- W2060496135 cites W2056631693 @default.
- W2060496135 cites W2056827933 @default.
- W2060496135 cites W2057654105 @default.
- W2060496135 cites W2065304353 @default.
- W2060496135 cites W2069434936 @default.
- W2060496135 cites W2069974281 @default.
- W2060496135 cites W2072307255 @default.
- W2060496135 cites W2074057410 @default.
- W2060496135 cites W2083366213 @default.
- W2060496135 cites W2096796564 @default.
- W2060496135 cites W2097948853 @default.
- W2060496135 cites W2105487944 @default.
- W2060496135 cites W2111217339 @default.
- W2060496135 cites W2117716312 @default.
- W2060496135 cites W2120752254 @default.
- W2060496135 cites W2121392264 @default.
- W2060496135 cites W2125118113 @default.
- W2060496135 cites W2126313739 @default.
- W2060496135 cites W2129612299 @default.
- W2060496135 cites W2131052578 @default.
- W2060496135 cites W2133951740 @default.
- W2060496135 cites W2135342180 @default.
- W2060496135 cites W2142565225 @default.
- W2060496135 cites W2146645063 @default.
- W2060496135 cites W2149676146 @default.
- W2060496135 cites W2149703257 @default.
- W2060496135 cites W2149750554 @default.
- W2060496135 cites W2151265435 @default.
- W2060496135 cites W2154797184 @default.
- W2060496135 cites W2155245588 @default.
- W2060496135 cites W2161678606 @default.
- W2060496135 cites W2163550224 @default.
- W2060496135 cites W2164347144 @default.
- W2060496135 cites W2165545825 @default.
- W2060496135 cites W2169333620 @default.
- W2060496135 cites W2171707138 @default.
- W2060496135 doi "https://doi.org/10.1534/genetics.106.055491" @default.
- W2060496135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1569706" @default.
- W2060496135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16783021" @default.
- W2060496135 hasPublicationYear "2006" @default.
- W2060496135 type Work @default.
- W2060496135 sameAs 2060496135 @default.
- W2060496135 citedByCount "18" @default.
- W2060496135 countsByYear W20604961352012 @default.
- W2060496135 countsByYear W20604961352013 @default.
- W2060496135 countsByYear W20604961352020 @default.
- W2060496135 crossrefType "journal-article" @default.
- W2060496135 hasAuthorship W2060496135A5011792309 @default.
- W2060496135 hasAuthorship W2060496135A5029881305 @default.
- W2060496135 hasAuthorship W2060496135A5045443541 @default.
- W2060496135 hasAuthorship W2060496135A5059987707 @default.
- W2060496135 hasAuthorship W2060496135A5070558214 @default.
- W2060496135 hasAuthorship W2060496135A5071827654 @default.
- W2060496135 hasBestOaLocation W20604961351 @default.
- W2060496135 hasConcept C104317684 @default.
- W2060496135 hasConcept C119056186 @default.
- W2060496135 hasConcept C180754005 @default.
- W2060496135 hasConcept C2777576037 @default.
- W2060496135 hasConcept C29537977 @default.
- W2060496135 hasConcept C54355233 @default.