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• W2060500374 abstract "Interleukin 17 promotes antibacterial and antifungal immune defenses. Hamilton and colleagues show that it induces complexes of the adaptors Act1 and TRAF2 or TRAF5 that inhibit the mRNA-destabilizing action of the splicing factor SF2 (ASF), thereby prolonging the half-life of chemokine and cytokine mRNAs. Interleukin 17 (IL-17) promotes the expression of chemokines and cytokines via the induction of gene transcription and post-transcriptional stabilization of mRNA. We show here that IL-17 enhanced the stability of chemokine CXCL1 mRNA and other mRNAs through a pathway that involved the adaptor Act1, the adaptors TRAF2 or TRAF5 and the splicing factor SF2 (also known as alternative splicing factor (ASF)). TRAF2 and TRAF5 were necessary for IL-17 to signal the stabilization of CXCL1 mRNA. Furthermore, IL-17 promoted the formation of complexes of TRAF5-TRAF2, Act1 and SF2 (ASF). Overexpression of SF2 (ASF) shortened the half-life of CXCL1 mRNA, whereas depletion of SF2 (ASF) prolonged it. SF2 (ASF) bound chemokine mRNA in unstimulated cells, whereas the SF2 (ASF)-mRNA interaction was much lower after stimulation with IL-17. Our findings define an IL-17-induced signaling pathway that links to the stabilization of selected mRNA species through Act1, TRAF2-TRAF5 and the RNA-binding protein SF2 (ASF)." @default.
• W2060500374 created "2016-06-24" @default.
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• W2060500374 date "2011-08-07" @default.
• W2060500374 modified "2023-10-08" @default.
• W2060500374 title "Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF)" @default.
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• W2060500374 doi "https://doi.org/10.1038/ni.2081" @default.
• W2060500374 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3597344" @default.
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