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- W2060513486 endingPage "24" @default.
- W2060513486 startingPage "14" @default.
- W2060513486 abstract "Apoptosis induced by p53 is firmly established as a central mechanism of tumour suppression. In addition to its complex functions as a nuclear transcription factor, p53 can act in the cytosol and mitochondria to promote apoptosis through transcription-independent mechanisms. Recent studies have shown that physical and functional interactions of p53 with various members of the Bcl-2 family provide the basis for this alternative route of p53-mediated cell death. However, different models of how these interactions promote apoptosis have been proposed. This review focuses on the mechanisms, regulation and physiological roles of transcription-independent p53 activities and highlights recent findings suggesting that the utilisation of these activities provides a promising alternative strategy for p53-based cancer therapy." @default.
- W2060513486 created "2016-06-24" @default.
- W2060513486 creator A5056547774 @default.
- W2060513486 date "2010-01-01" @default.
- W2060513486 modified "2023-10-18" @default.
- W2060513486 title "Transcription-independent p53 apoptosis: an alternative route to death" @default.
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