FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060521691> ?p ?o ?g. }

• W2060521691 endingPage "e111605" @default.
• W2060521691 startingPage "e111605" @default.
• W2060521691 abstract "Bluetongue virus (BTV) is an economically important Orbivirus transmitted by biting midges to domestic and wild ruminants. The need for new vaccines has been highlighted by the occurrence of repeated outbreaks caused by different BTV serotypes since 1998. The major group-reactive antigen of BTV, VP7, is conserved in the 26 serotypes described so far, and its role in the induction of protective immunity has been proposed. Viral-based vectors as antigen delivery systems display considerable promise as veterinary vaccine candidates. In this paper we have evaluated the capacity of the BTV-2 serotype VP7 core protein expressed by either a non-replicative canine adenovirus type 2 (Cav-VP7 R0) or a leporipoxvirus (SG33-VP7), to induce immune responses in sheep. Humoral responses were elicited against VP7 in almost all animals that received the recombinant vectors. Both Cav-VP7 R0 and SG33-VP7 stimulated an antigen-specific CD4+ response and Cav-VP7 R0 stimulated substantial proliferation of antigen-specific CD8+ lymphocytes. Encouraged by the results obtained with the Cav-VP7 R0 vaccine vector, immunized animals were challenged with either the homologous BTV-2 or the heterologous BTV-8 serotype and viral burden in plasma was followed by real-time RT-PCR. The immune responses triggered by Cav-VP7 R0 were insufficient to afford protective immunity against BTV infection, despite partial protection obtained against homologous challenge. This work underscores the need to further characterize the role of BTV proteins in cross-protective immunity." @default.
• W2060521691 created "2016-06-24" @default.
• W2060521691 creator A5001152735 @default.
• W2060521691 creator A5001340881 @default.
• W2060521691 creator A5004376586 @default.
• W2060521691 creator A5009224482 @default.
• W2060521691 creator A5014556698 @default.
• W2060521691 creator A5018028566 @default.
• W2060521691 creator A5020876094 @default.
• W2060521691 creator A5021989531 @default.
• W2060521691 creator A5025942581 @default.
• W2060521691 creator A5028992313 @default.
• W2060521691 creator A5030941419 @default.
• W2060521691 creator A5049751402 @default.
• W2060521691 creator A5055782699 @default.
• W2060521691 creator A5066176078 @default.
• W2060521691 creator A5067236114 @default.
• W2060521691 creator A5077073756 @default.
• W2060521691 creator A5077177917 @default.
• W2060521691 creator A5080080418 @default.
• W2060521691 creator A5084459435 @default.
• W2060521691 creator A5085526997 @default.
• W2060521691 date "2014-11-03" @default.
• W2060521691 modified "2023-10-17" @default.
• W2060521691 title "Expression of VP7, a Bluetongue Virus Group Specific Antigen by Viral Vectors: Analysis of the Induced Immune Responses and Evaluation of Protective Potential in Sheep" @default.
• W2060521691 cites W144794033 @default.
• W2060521691 cites W1975016491 @default.
• W2060521691 cites W1977890114 @default.
• W2060521691 cites W1978346615 @default.
• W2060521691 cites W1978822770 @default.
• W2060521691 cites W1984768211 @default.
• W2060521691 cites W1986640779 @default.
• W2060521691 cites W1997410627 @default.
• W2060521691 cites W1999258330 @default.
• W2060521691 cites W2005855364 @default.
• W2060521691 cites W2008409414 @default.
• W2060521691 cites W2008955854 @default.
• W2060521691 cites W2010110487 @default.
• W2060521691 cites W2010563925 @default.
• W2060521691 cites W2011758195 @default.
• W2060521691 cites W2017468538 @default.
• W2060521691 cites W2023973316 @default.
• W2060521691 cites W2027112869 @default.
• W2060521691 cites W2054678965 @default.
• W2060521691 cites W2065657994 @default.
• W2060521691 cites W2068687644 @default.
• W2060521691 cites W2070877714 @default.
• W2060521691 cites W2072362354 @default.
• W2060521691 cites W2076074537 @default.
• W2060521691 cites W2089427300 @default.
• W2060521691 cites W2093193202 @default.
• W2060521691 cites W2093913169 @default.
• W2060521691 cites W2096782739 @default.
• W2060521691 cites W2097521399 @default.
• W2060521691 cites W2102403254 @default.
• W2060521691 cites W2109129182 @default.
• W2060521691 cites W2119137829 @default.
• W2060521691 cites W2121672863 @default.
• W2060521691 cites W2127466559 @default.
• W2060521691 cites W2135945199 @default.
• W2060521691 cites W2151761036 @default.
• W2060521691 cites W2152975905 @default.
• W2060521691 cites W4298028742 @default.
• W2060521691 doi "https://doi.org/10.1371/journal.pone.0111605" @default.
• W2060521691 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4218782" @default.
• W2060521691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25364822" @default.
• W2060521691 hasPublicationYear "2014" @default.
• W2060521691 type Work @default.
• W2060521691 sameAs 2060521691 @default.
• W2060521691 citedByCount "14" @default.
• W2060521691 countsByYear W20605216912015 @default.
• W2060521691 countsByYear W20605216912016 @default.
• W2060521691 countsByYear W20605216912017 @default.
• W2060521691 countsByYear W20605216912018 @default.
• W2060521691 countsByYear W20605216912019 @default.
• W2060521691 countsByYear W20605216912020 @default.
• W2060521691 countsByYear W20605216912021 @default.
• W2060521691 countsByYear W20605216912022 @default.
• W2060521691 countsByYear W20605216912023 @default.
• W2060521691 crossrefType "journal-article" @default.
• W2060521691 hasAuthorship W2060521691A5001152735 @default.
• W2060521691 hasAuthorship W2060521691A5001340881 @default.
• W2060521691 hasAuthorship W2060521691A5004376586 @default.
• W2060521691 hasAuthorship W2060521691A5009224482 @default.
• W2060521691 hasAuthorship W2060521691A5014556698 @default.
• W2060521691 hasAuthorship W2060521691A5018028566 @default.
• W2060521691 hasAuthorship W2060521691A5020876094 @default.
• W2060521691 hasAuthorship W2060521691A5021989531 @default.
• W2060521691 hasAuthorship W2060521691A5025942581 @default.
• W2060521691 hasAuthorship W2060521691A5028992313 @default.
• W2060521691 hasAuthorship W2060521691A5030941419 @default.
• W2060521691 hasAuthorship W2060521691A5049751402 @default.
• W2060521691 hasAuthorship W2060521691A5055782699 @default.
• W2060521691 hasAuthorship W2060521691A5066176078 @default.
• W2060521691 hasAuthorship W2060521691A5067236114 @default.
• W2060521691 hasAuthorship W2060521691A5077073756 @default.
• W2060521691 hasAuthorship W2060521691A5077177917 @default.
• W2060521691 hasAuthorship W2060521691A5080080418 @default.

• next