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- W2060522044 abstract "Since the introduction of glucose-insulin-potassium therapy for acute myocardial infarction 20 years ago, there have been many attempts to determine the efficacy of this treatment. Some trials have shown that this therapy is antiarrhythmic and others have found no benefit. In this study we demonstrate that concentrations of glucose found to be antlarrhythmic in recent clinical trials exert favorable effects on resting membrane potential, overshoot, and rising velocity in hypoxic canine heart cells. The refractory period, shortened by hypoxia, is also significantly lengthened by extra glucose. All of these single-cell effects are potentially antiarrhythmic and may explain the effectiveness of this therapy." @default.
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- W2060522044 date "1983-10-01" @default.
- W2060522044 modified "2023-09-23" @default.
- W2060522044 title "Effects of glucose on the transmembrane potential of hypoxic canine ventricular muscle fibers" @default.
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- W2060522044 doi "https://doi.org/10.1016/0002-8703(83)90085-6" @default.
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