Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060524849> ?p ?o ?g. }
- W2060524849 endingPage "57" @default.
- W2060524849 startingPage "48" @default.
- W2060524849 abstract "Summary: In this review, we briefly cover the critical requirements for interleukin‐7 (IL‐7) in thymocyte development and peripheral T‐cell homeostasis. Part of the IL‐7 effect is antiapoptotic or ‘trophic’ and we have studied the intracellular pathways involved in lymphocyte survival and death regulated by this cytokine. We review the evidence for a role of the JAK signal transducers and activators of transcription protein (STAT) pathway and phosphoinositide 3‐kinase (PI3K)–AKT pathways in survival. The death pathway following IL‐7 withdrawal is discussed in terms of the balance of BCL‐2 vs. BAX and other death proteins and the role of metabolic disturbances involving glucose metabolism and intracellular pH. The IL‐7 survival and death pathways in lymphocytes may be representative of many trophic factors in different cell types; yet we conclude that much of the mechanism remains to be discovered." @default.
- W2060524849 created "2016-06-24" @default.
- W2060524849 creator A5021394893 @default.
- W2060524849 creator A5080097687 @default.
- W2060524849 date "2003-05-12" @default.
- W2060524849 modified "2023-10-15" @default.
- W2060524849 title "Death and Baxes: mechanisms of lymphotrophic cytokines" @default.
- W2060524849 cites W1521515468 @default.
- W2060524849 cites W1524516556 @default.
- W2060524849 cites W1537543309 @default.
- W2060524849 cites W1575016278 @default.
- W2060524849 cites W1593219141 @default.
- W2060524849 cites W1601504908 @default.
- W2060524849 cites W1606738305 @default.
- W2060524849 cites W1748564991 @default.
- W2060524849 cites W1895524259 @default.
- W2060524849 cites W1931387024 @default.
- W2060524849 cites W1947563713 @default.
- W2060524849 cites W1966432380 @default.
- W2060524849 cites W1972658032 @default.
- W2060524849 cites W1974659740 @default.
- W2060524849 cites W1974906492 @default.
- W2060524849 cites W1975753425 @default.
- W2060524849 cites W1981166298 @default.
- W2060524849 cites W1983194131 @default.
- W2060524849 cites W1983672911 @default.
- W2060524849 cites W1984547206 @default.
- W2060524849 cites W1991381808 @default.
- W2060524849 cites W1992031335 @default.
- W2060524849 cites W1993206112 @default.
- W2060524849 cites W1995297089 @default.
- W2060524849 cites W1998373798 @default.
- W2060524849 cites W2005613406 @default.
- W2060524849 cites W2008366157 @default.
- W2060524849 cites W2008597649 @default.
- W2060524849 cites W2011785467 @default.
- W2060524849 cites W2012408584 @default.
- W2060524849 cites W2013928717 @default.
- W2060524849 cites W2018038111 @default.
- W2060524849 cites W2023632476 @default.
- W2060524849 cites W2025465431 @default.
- W2060524849 cites W2026873116 @default.
- W2060524849 cites W2028091596 @default.
- W2060524849 cites W2029735625 @default.
- W2060524849 cites W2030573603 @default.
- W2060524849 cites W2031141836 @default.
- W2060524849 cites W2032049833 @default.
- W2060524849 cites W2032592355 @default.
- W2060524849 cites W2033801757 @default.
- W2060524849 cites W2034433166 @default.
- W2060524849 cites W2036274324 @default.
- W2060524849 cites W2043066069 @default.
- W2060524849 cites W2050477129 @default.
- W2060524849 cites W2062853648 @default.
- W2060524849 cites W2065388713 @default.
- W2060524849 cites W2065601509 @default.
- W2060524849 cites W2075477970 @default.
- W2060524849 cites W2085555998 @default.
- W2060524849 cites W2086050331 @default.
- W2060524849 cites W2086680916 @default.
- W2060524849 cites W2087832707 @default.
- W2060524849 cites W2088805436 @default.
- W2060524849 cites W2092353041 @default.
- W2060524849 cites W2096632716 @default.
- W2060524849 cites W2097767970 @default.
- W2060524849 cites W2098403002 @default.
- W2060524849 cites W2108197605 @default.
- W2060524849 cites W2113439647 @default.
- W2060524849 cites W2122830690 @default.
- W2060524849 cites W2129860342 @default.
- W2060524849 cites W2129945440 @default.
- W2060524849 cites W2130098661 @default.
- W2060524849 cites W2132544581 @default.
- W2060524849 cites W2134979684 @default.
- W2060524849 cites W2137035181 @default.
- W2060524849 cites W2138892400 @default.
- W2060524849 cites W2139410381 @default.
- W2060524849 cites W2141231618 @default.
- W2060524849 cites W2142285575 @default.
- W2060524849 cites W2146983373 @default.
- W2060524849 cites W2147114673 @default.
- W2060524849 cites W2147246759 @default.
- W2060524849 cites W2148668423 @default.
- W2060524849 cites W2157740207 @default.
- W2060524849 cites W2162743131 @default.
- W2060524849 cites W2163579392 @default.
- W2060524849 cites W2165495560 @default.
- W2060524849 cites W2166601968 @default.
- W2060524849 cites W2169232755 @default.
- W2060524849 cites W2316973523 @default.
- W2060524849 cites W2326387362 @default.
- W2060524849 cites W315516960 @default.
- W2060524849 cites W4313331553 @default.
- W2060524849 cites W4313342479 @default.
- W2060524849 cites W54799151 @default.
- W2060524849 doi "https://doi.org/10.1034/j.1600-065x.2003.00050.x" @default.
- W2060524849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12752670" @default.
- W2060524849 hasPublicationYear "2003" @default.