FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060546213> ?p ?o ?g. }

• W2060546213 endingPage "534" @default.
• W2060546213 startingPage "525" @default.
• W2060546213 abstract "Introduction: There is an urgent need for preclinical testing systems that more accurately reflect responses in human target organs. The use of ex vivo tissues taken out of the human body and kept alive for sufficient time to perform testing has until recently been limited by tissue availability and by the length of time tissues can be kept alive outside the body, however, recent advances in tissue handling and tissue culture techniques have now made it possible to envisage using such tissues for drug discovery on a scale that is of value for the evaluation of compounds prior to testing in humans. Areas covered: The article presents a method for generating 3D microtissues at the air–liquid interface ‘OrganDots’ which are formed by reaggregating primary tissues or stem cell-based material which may be useful in drug discovery and development. The article compares this method with other methods for obtaining ex vivo tissues and looks at their uses as surrogates to testing compounds in humans. Expert opinion: Reconstituting tissues in vitro has now reached a point where they can be used to profile the activity of compounds prior to in vivo testing. The ability to reconstitute tissues from primary material and the ability to synthesize new tissues in vitro from stem cells may lead to new testing systems that better reflect human pathophysiology and may allow individual differences to be expressed in vitro. These new drug testing systems should lead to more predictable in vitro drug testing systems in the near future." @default.
• W2060546213 created "2016-06-24" @default.
• W2060546213 creator A5013706821 @default.
• W2060546213 creator A5027476457 @default.
• W2060546213 creator A5085343813 @default.
• W2060546213 creator A5086778438 @default.
• W2060546213 date "2012-05-19" @default.
• W2060546213 modified "2023-10-14" @default.
• W2060546213 title "OrganDots – an organotypic 3D tissue culture platform for drug development" @default.
• W2060546213 cites W104322370 @default.
• W2060546213 cites W1786253659 @default.
• W2060546213 cites W1853186204 @default.
• W2060546213 cites W1929908732 @default.
• W2060546213 cites W1979169277 @default.
• W2060546213 cites W1979691814 @default.
• W2060546213 cites W1985133253 @default.
• W2060546213 cites W1990773110 @default.
• W2060546213 cites W1993909726 @default.
• W2060546213 cites W1994237305 @default.
• W2060546213 cites W1998700528 @default.
• W2060546213 cites W1998734023 @default.
• W2060546213 cites W2004875910 @default.
• W2060546213 cites W2005092240 @default.
• W2060546213 cites W2009168006 @default.
• W2060546213 cites W2010251891 @default.
• W2060546213 cites W2015986915 @default.
• W2060546213 cites W2017394391 @default.
• W2060546213 cites W2018504096 @default.
• W2060546213 cites W2026105950 @default.
• W2060546213 cites W2033474014 @default.
• W2060546213 cites W2033643156 @default.
• W2060546213 cites W2042332803 @default.
• W2060546213 cites W2044056099 @default.
• W2060546213 cites W2045387133 @default.
• W2060546213 cites W2046299552 @default.
• W2060546213 cites W2058196652 @default.
• W2060546213 cites W2060801754 @default.
• W2060546213 cites W2068096393 @default.
• W2060546213 cites W2076299452 @default.
• W2060546213 cites W2079054696 @default.
• W2060546213 cites W2080923518 @default.
• W2060546213 cites W2082554707 @default.
• W2060546213 cites W2097862336 @default.
• W2060546213 cites W2098177200 @default.
• W2060546213 cites W2101167135 @default.
• W2060546213 cites W2107980872 @default.
• W2060546213 cites W2141667977 @default.
• W2060546213 cites W2145492799 @default.
• W2060546213 cites W2152635048 @default.
• W2060546213 cites W2157615753 @default.
• W2060546213 cites W2168956427 @default.
• W2060546213 cites W2170806689 @default.
• W2060546213 cites W2171617589 @default.
• W2060546213 cites W2406703098 @default.
• W2060546213 cites W4249346408 @default.
• W2060546213 doi "https://doi.org/10.1517/17460441.2012.686488" @default.
• W2060546213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22607235" @default.
• W2060546213 hasPublicationYear "2012" @default.
• W2060546213 type Work @default.
• W2060546213 sameAs 2060546213 @default.
• W2060546213 citedByCount "9" @default.
• W2060546213 countsByYear W20605462132012 @default.
• W2060546213 countsByYear W20605462132014 @default.
• W2060546213 countsByYear W20605462132017 @default.
• W2060546213 countsByYear W20605462132019 @default.
• W2060546213 countsByYear W20605462132020 @default.
• W2060546213 crossrefType "journal-article" @default.
• W2060546213 hasAuthorship W2060546213A5013706821 @default.
• W2060546213 hasAuthorship W2060546213A5027476457 @default.
• W2060546213 hasAuthorship W2060546213A5085343813 @default.
• W2060546213 hasAuthorship W2060546213A5086778438 @default.
• W2060546213 hasConcept C150903083 @default.
• W2060546213 hasConcept C202751555 @default.
• W2060546213 hasConcept C207001950 @default.
• W2060546213 hasConcept C26291073 @default.
• W2060546213 hasConcept C2780035454 @default.
• W2060546213 hasConcept C55493867 @default.
• W2060546213 hasConcept C60644358 @default.
• W2060546213 hasConcept C64903051 @default.
• W2060546213 hasConcept C70721500 @default.
• W2060546213 hasConcept C74187038 @default.
• W2060546213 hasConcept C86803240 @default.
• W2060546213 hasConcept C90703135 @default.
• W2060546213 hasConcept C98274493 @default.
• W2060546213 hasConceptScore W2060546213C150903083 @default.
• W2060546213 hasConceptScore W2060546213C202751555 @default.
• W2060546213 hasConceptScore W2060546213C207001950 @default.
• W2060546213 hasConceptScore W2060546213C26291073 @default.
• W2060546213 hasConceptScore W2060546213C2780035454 @default.
• W2060546213 hasConceptScore W2060546213C55493867 @default.
• W2060546213 hasConceptScore W2060546213C60644358 @default.
• W2060546213 hasConceptScore W2060546213C64903051 @default.
• W2060546213 hasConceptScore W2060546213C70721500 @default.
• W2060546213 hasConceptScore W2060546213C74187038 @default.
• W2060546213 hasConceptScore W2060546213C86803240 @default.
• W2060546213 hasConceptScore W2060546213C90703135 @default.
• W2060546213 hasConceptScore W2060546213C98274493 @default.
• W2060546213 hasIssue "6" @default.

• next