FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060550948> ?p ?o ?g. }

• W2060550948 endingPage "368" @default.
• W2060550948 startingPage "363" @default.
• W2060550948 abstract "In previous studies in which the anti-pentylenetetrazol (PTZ) effect of benzodiazepines was used to measure tolerance, the results depended on the benzodiazepine used for chronic treatment as well as the benzodiazepine given acutely to test for tolerance. In this study, the time course of tolerance reversal was studied in rats given two treatments known to cause anticonvulsant tolerance, 1-week flurazepam (FZP), and 3-week diazepam (DZP). Neither treatment altered convulsive threshold for IV PTZ, but both treatments decreased the convulsive threshold for bicuculline. Withdrawing DZP, but not FZP, treatment resulted in a loss of body weight. Twelve hours after 1-week FZP treatment, all benzodiazepines were significantly less effective, showing tolerance. Forty-eight hours after the 1-week FZP treatment, tolerance was still observed with DZP, FZP, and zolpidem, but was no longer present with clonazepam or bretazenil. After the 3-week DZP treatment, rats were tolerant to all benzodiazepines tested at 12 h of withdrawal, but had lost tolerance to all the drugs except bretazenil by 48 h. The results suggest differences in the way these benzodiazepines interact with their receptors, allowing differential expression of tolerance, and that chronic DZP and FZP treatments affected interactions of the benzodiazepines with their receptors, but not in the same fashion." @default.
• W2060550948 created "2016-06-24" @default.
• W2060550948 creator A5045289644 @default.
• W2060550948 date "1995-06-01" @default.
• W2060550948 modified "2023-09-23" @default.
• W2060550948 title "Differential expression of benzodiazepine anticonvulsant cross-tolerance according to time following flurazepam or diazepam treatment" @default.
• W2060550948 cites W1518951878 @default.
• W2060550948 cites W1967062110 @default.
• W2060550948 cites W1968187813 @default.
• W2060550948 cites W1974911055 @default.
• W2060550948 cites W1984051577 @default.
• W2060550948 cites W1987059345 @default.
• W2060550948 cites W1990402164 @default.
• W2060550948 cites W1996085257 @default.
• W2060550948 cites W1998473188 @default.
• W2060550948 cites W2004086821 @default.
• W2060550948 cites W2011400643 @default.
• W2060550948 cites W2023697748 @default.
• W2060550948 cites W2024535965 @default.
• W2060550948 cites W2028229320 @default.
• W2060550948 cites W2028802103 @default.
• W2060550948 cites W2030980141 @default.
• W2060550948 cites W2032218383 @default.
• W2060550948 cites W2035350149 @default.
• W2060550948 cites W2042127335 @default.
• W2060550948 cites W2042976056 @default.
• W2060550948 cites W2050349038 @default.
• W2060550948 cites W2051658048 @default.
• W2060550948 cites W2054507565 @default.
• W2060550948 cites W2056137472 @default.
• W2060550948 cites W2058308027 @default.
• W2060550948 cites W2060088347 @default.
• W2060550948 cites W2062971299 @default.
• W2060550948 cites W2072423067 @default.
• W2060550948 cites W2078223791 @default.
• W2060550948 cites W2088450552 @default.
• W2060550948 cites W2090514027 @default.
• W2060550948 cites W2094151893 @default.
• W2060550948 cites W2099417843 @default.
• W2060550948 cites W2100488616 @default.
• W2060550948 cites W2130856363 @default.
• W2060550948 doi "https://doi.org/10.1016/0091-3057(94)00405-8" @default.
• W2060550948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7667354" @default.
• W2060550948 hasPublicationYear "1995" @default.
• W2060550948 type Work @default.
• W2060550948 sameAs 2060550948 @default.
• W2060550948 citedByCount "25" @default.
• W2060550948 countsByYear W20605509482014 @default.
• W2060550948 countsByYear W20605509482018 @default.
• W2060550948 crossrefType "journal-article" @default.
• W2060550948 hasAuthorship W2060550948A5045289644 @default.
• W2060550948 hasConcept C118552586 @default.
• W2060550948 hasConcept C126322002 @default.
• W2060550948 hasConcept C168258287 @default.
• W2060550948 hasConcept C170493617 @default.
• W2060550948 hasConcept C2775858608 @default.
• W2060550948 hasConcept C2776156762 @default.
• W2060550948 hasConcept C2776175493 @default.
• W2060550948 hasConcept C2776819090 @default.
• W2060550948 hasConcept C2777123777 @default.
• W2060550948 hasConcept C2777389121 @default.
• W2060550948 hasConcept C2778173252 @default.
• W2060550948 hasConcept C2778186239 @default.
• W2060550948 hasConcept C2778325228 @default.
• W2060550948 hasConcept C2779426884 @default.
• W2060550948 hasConcept C2779985140 @default.
• W2060550948 hasConcept C2781210498 @default.
• W2060550948 hasConcept C42219234 @default.
• W2060550948 hasConcept C71924100 @default.
• W2060550948 hasConcept C946728 @default.
• W2060550948 hasConcept C98274493 @default.
• W2060550948 hasConceptScore W2060550948C118552586 @default.
• W2060550948 hasConceptScore W2060550948C126322002 @default.
• W2060550948 hasConceptScore W2060550948C168258287 @default.
• W2060550948 hasConceptScore W2060550948C170493617 @default.
• W2060550948 hasConceptScore W2060550948C2775858608 @default.
• W2060550948 hasConceptScore W2060550948C2776156762 @default.
• W2060550948 hasConceptScore W2060550948C2776175493 @default.
• W2060550948 hasConceptScore W2060550948C2776819090 @default.
• W2060550948 hasConceptScore W2060550948C2777123777 @default.
• W2060550948 hasConceptScore W2060550948C2777389121 @default.
• W2060550948 hasConceptScore W2060550948C2778173252 @default.
• W2060550948 hasConceptScore W2060550948C2778186239 @default.
• W2060550948 hasConceptScore W2060550948C2778325228 @default.
• W2060550948 hasConceptScore W2060550948C2779426884 @default.
• W2060550948 hasConceptScore W2060550948C2779985140 @default.
• W2060550948 hasConceptScore W2060550948C2781210498 @default.
• W2060550948 hasConceptScore W2060550948C42219234 @default.
• W2060550948 hasConceptScore W2060550948C71924100 @default.
• W2060550948 hasConceptScore W2060550948C946728 @default.
• W2060550948 hasConceptScore W2060550948C98274493 @default.
• W2060550948 hasIssue "2-3" @default.
• W2060550948 hasLocation W20605509481 @default.
• W2060550948 hasLocation W20605509482 @default.
• W2060550948 hasOpenAccess W2060550948 @default.
• W2060550948 hasPrimaryLocation W20605509481 @default.
• W2060550948 hasRelatedWork W1518951878 @default.
• W2060550948 hasRelatedWork W1971864901 @default.

• next