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• W2060555087 abstract "A 6-step solid phase sequence towards C2,N6-disubstituted adenosine analogues was developed, which was validated by the construction of a small combinatorial library. Attachment of the 5′-OH of readily available 2′,3′-methoxymethylidene protected 6-chloropurine ribonucleoside onto carboxypolystyrene furnished the immobilised 6-chloropurine ribonucleoside. Nitration on the solid phase resulted in the formation of the 2-nitro-6-chloropurine nucleoside, a highly reactive difunctionalised species. Amines were selectively introduced at the 6-position by 6-chloro displacement at room temperature without affecting the 2-nitro group. Subsequent substitution of the 2-nitro group by amines was achieved at 80–90 °C. Removal of the methoxymethylidene group under mildly acidic conditions, followed by cleavage of the nucleosides from the resin, yielded the C2,N6-disubstituted adenosine analogues." @default.
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• W2060555087 date "2002-04-24" @default.
• W2060555087 modified "2023-09-27" @default.
• W2060555087 title "Solid phase synthesis of C2,N6-disubstituted adenosine analogues" @default.
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• W2060555087 doi "https://doi.org/10.1039/b201943d" @default.
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