FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060567681> ?p ?o ?g. }

• W2060567681 endingPage "1130" @default.
• W2060567681 startingPage "1119" @default.
• W2060567681 abstract "The effect of hydrodynamic forces on animal cell cultures, while extensively studied, still lacks significant, fundamental understanding. A previous manuscript reported on the acute exposure of CHO cells to hydrodynamic forces in a second generation convergent–divergent microfluidic device (Mollet et al., 2007). In this study, the use of this device is extended in a proof of concept system in which suspended animal cells, grown in a typical bioreactor, are subjected to chronic exposure of moderately high levels of hydrodynamic forces by way of a continuous recycle loop between the bioreactor and the microfluidic device. A strain of CHO cells (CHO-6E6) was grown in a batch culture under controlled pH, temperature, and dissolved oxygen conditions. At mid exponential stage of growth in the bioreactor the recycle flow was initiated. The cells either stopped growing or started dying at EDR values that were significantly lower (one to two orders of magnitude) than those previously reported to kill cells from a single, acute exposure. These observations allow further refinement in the design of bioprocess equipment since it provides a more accurate threshold, above which one does not want to subject animal cells to continuous exposure to specific levels of hydrodynamic forces. Biotechnol. Bioeng. 2009;102: 1119–1130. © 2008 Wiley Periodicals, Inc." @default.
• W2060567681 created "2016-06-24" @default.
• W2060567681 creator A5029632197 @default.
• W2060567681 creator A5077991708 @default.
• W2060567681 creator A5081489704 @default.
• W2060567681 date "2009-03-01" @default.
• W2060567681 modified "2023-10-18" @default.
• W2060567681 title "Evaluation of the effect of chronic hydrodynamical stresses on cultures of suspensed CHO-6E6 cells" @default.
• W2060567681 cites W1976880017 @default.
• W2060567681 cites W1979068443 @default.
• W2060567681 cites W1980236358 @default.
• W2060567681 cites W1986676509 @default.
• W2060567681 cites W1993950717 @default.
• W2060567681 cites W1995977817 @default.
• W2060567681 cites W2007320036 @default.
• W2060567681 cites W2010906979 @default.
• W2060567681 cites W2011033732 @default.
• W2060567681 cites W2013276474 @default.
• W2060567681 cites W2013861871 @default.
• W2060567681 cites W2025330588 @default.
• W2060567681 cites W2033420958 @default.
• W2060567681 cites W2038295106 @default.
• W2060567681 cites W2039331584 @default.
• W2060567681 cites W2039684693 @default.
• W2060567681 cites W2042517511 @default.
• W2060567681 cites W2048599687 @default.
• W2060567681 cites W2049767145 @default.
• W2060567681 cites W2052463027 @default.
• W2060567681 cites W2061226704 @default.
• W2060567681 cites W2065456585 @default.
• W2060567681 cites W2067949255 @default.
• W2060567681 cites W2073958645 @default.
• W2060567681 cites W2080255164 @default.
• W2060567681 cites W2080410730 @default.
• W2060567681 cites W2080826463 @default.
• W2060567681 cites W2126556493 @default.
• W2060567681 cites W2131740110 @default.
• W2060567681 cites W2139132159 @default.
• W2060567681 cites W2160079461 @default.
• W2060567681 cites W2171877643 @default.
• W2060567681 cites W62193260 @default.
• W2060567681 doi "https://doi.org/10.1002/bit.22146" @default.
• W2060567681 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18958864" @default.
• W2060567681 hasPublicationYear "2009" @default.
• W2060567681 type Work @default.
• W2060567681 sameAs 2060567681 @default.
• W2060567681 citedByCount "40" @default.
• W2060567681 countsByYear W20605676812013 @default.
• W2060567681 countsByYear W20605676812014 @default.
• W2060567681 countsByYear W20605676812015 @default.
• W2060567681 countsByYear W20605676812016 @default.
• W2060567681 countsByYear W20605676812017 @default.
• W2060567681 countsByYear W20605676812018 @default.
• W2060567681 countsByYear W20605676812020 @default.
• W2060567681 countsByYear W20605676812021 @default.
• W2060567681 countsByYear W20605676812022 @default.
• W2060567681 countsByYear W20605676812023 @default.
• W2060567681 crossrefType "journal-article" @default.
• W2060567681 hasAuthorship W2060567681A5029632197 @default.
• W2060567681 hasAuthorship W2060567681A5077991708 @default.
• W2060567681 hasAuthorship W2060567681A5081489704 @default.
• W2060567681 hasConcept C105702510 @default.
• W2060567681 hasConcept C121332964 @default.
• W2060567681 hasConcept C12554922 @default.
• W2060567681 hasConcept C127413603 @default.
• W2060567681 hasConcept C168170006 @default.
• W2060567681 hasConcept C171250308 @default.
• W2060567681 hasConcept C175656101 @default.
• W2060567681 hasConcept C178790620 @default.
• W2060567681 hasConcept C183696295 @default.
• W2060567681 hasConcept C185592680 @default.
• W2060567681 hasConcept C186060115 @default.
• W2060567681 hasConcept C192562407 @default.
• W2060567681 hasConcept C2778022156 @default.
• W2060567681 hasConcept C2985264121 @default.
• W2060567681 hasConcept C42360764 @default.
• W2060567681 hasConcept C4916135 @default.
• W2060567681 hasConcept C54355233 @default.
• W2060567681 hasConcept C62520636 @default.
• W2060567681 hasConcept C75235859 @default.
• W2060567681 hasConcept C81885089 @default.
• W2060567681 hasConcept C8673954 @default.
• W2060567681 hasConcept C86803240 @default.
• W2060567681 hasConceptScore W2060567681C105702510 @default.
• W2060567681 hasConceptScore W2060567681C121332964 @default.
• W2060567681 hasConceptScore W2060567681C12554922 @default.
• W2060567681 hasConceptScore W2060567681C127413603 @default.
• W2060567681 hasConceptScore W2060567681C168170006 @default.
• W2060567681 hasConceptScore W2060567681C171250308 @default.
• W2060567681 hasConceptScore W2060567681C175656101 @default.
• W2060567681 hasConceptScore W2060567681C178790620 @default.
• W2060567681 hasConceptScore W2060567681C183696295 @default.
• W2060567681 hasConceptScore W2060567681C185592680 @default.
• W2060567681 hasConceptScore W2060567681C186060115 @default.
• W2060567681 hasConceptScore W2060567681C192562407 @default.
• W2060567681 hasConceptScore W2060567681C2778022156 @default.
• W2060567681 hasConceptScore W2060567681C2985264121 @default.
• W2060567681 hasConceptScore W2060567681C42360764 @default.

• next