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- W2060569935 abstract "Asymmetric total synthesis of bryostatin 16 was achieved in 26 steps in the longest linear sequence and in 39 total steps from aldehyde 10. A Pd-catalyzed alkyne−alkyne coupling was employed for the first time as a macrocyclization method in a natural product synthesis. A route to convert bryostatin 16 to a new family of bryostatin analogues was developed. Toward this end, 20-epi-bryostatin 7 was synthesized from a bryostatin 16-like intermediate; the key step involves a Re-catalyzed epoxidation/ring-opening reaction. Preliminary biological studies indicated that this new analogue exhibits nanomolar anti-cancer activity against several cancer cell lines." @default.
- W2060569935 created "2016-06-24" @default.
- W2060569935 creator A5023312754 @default.
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- W2060569935 date "2010-11-02" @default.
- W2060569935 modified "2023-10-12" @default.
- W2060569935 title "Total Synthesis of Bryostatin 16 Using a Pd-Catalyzed Diyne Coupling as Macrocyclization Method and Synthesis of C20-<i>epi</i>-Bryostatin 7 as a Potent Anticancer Agent" @default.
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- W2060569935 doi "https://doi.org/10.1021/ja105129p" @default.
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