FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060602021> ?p ?o ?g. }

• W2060602021 endingPage "3663" @default.
• W2060602021 startingPage "3655" @default.
• W2060602021 abstract "Abstract B cell fate is determined by the strength of signals from the antigen receptor and from co‐receptors that adjust the activation threshold and tune the B cell to its environment. These co‐receptors have been broadly classified into inhibitory and enhancing groups, yet some, such as CD22, may have dual effects. CD22 recruits a variety of signal enhancers at the same time as Lyn‐dependent phosphorylation leads to the binding of the inhibitory phosphatase SHP‐1. To assess the relative importance of Lyn‐ and CD22‐dependent and ‐independent pathways, we generated Lyn and CD22 single‐deficient mice and Lyn/CD22 double‐deficient mice expressing the MD4 immunoglobulin transgene against hen egg lysozyme (Ig HEL ). This genetic approach has enabled us to compare the contributions of Lyn and CD22 to B cell development in vivo , independent of BCR specificity and in the presence and absence of self‐antigen. Our results show that although the effects of Lyn are dominant in negative regulation of B cell hyperactivity, Lyn and CD22 have independent and additive effects on B cell survival. These findings emphasize the subtle nature of regulation at the BCR and the usefulness of genetic complementation to dissect common and parallel pathways." @default.
• W2060602021 created "2016-06-24" @default.
• W2060602021 creator A5001353518 @default.
• W2060602021 creator A5030700291 @default.
• W2060602021 creator A5042698206 @default.
• W2060602021 creator A5061788017 @default.
• W2060602021 creator A5070851567 @default.
• W2060602021 creator A5075122404 @default.
• W2060602021 date "2005-12-01" @default.
• W2060602021 modified "2023-10-17" @default.
• W2060602021 title "Analysis of Lyn/CD22 double-deficient B cellsin vivo demonstrates Lyn- and CD22-independent pathways affecting BCR regulation and B cell survival" @default.
• W2060602021 cites W1563889021 @default.
• W2060602021 cites W1589053023 @default.
• W2060602021 cites W1591740730 @default.
• W2060602021 cites W1592923741 @default.
• W2060602021 cites W1903572164 @default.
• W2060602021 cites W1936384564 @default.
• W2060602021 cites W1965503707 @default.
• W2060602021 cites W1966949480 @default.
• W2060602021 cites W1972861232 @default.
• W2060602021 cites W1979977043 @default.
• W2060602021 cites W1984198105 @default.
• W2060602021 cites W1986150526 @default.
• W2060602021 cites W1995538143 @default.
• W2060602021 cites W1996486759 @default.
• W2060602021 cites W2004473774 @default.
• W2060602021 cites W2011443550 @default.
• W2060602021 cites W2021716242 @default.
• W2060602021 cites W2023216402 @default.
• W2060602021 cites W2028744022 @default.
• W2060602021 cites W2029602090 @default.
• W2060602021 cites W2030540193 @default.
• W2060602021 cites W2030793757 @default.
• W2060602021 cites W2031026925 @default.
• W2060602021 cites W2034815827 @default.
• W2060602021 cites W2049862010 @default.
• W2060602021 cites W2054513471 @default.
• W2060602021 cites W2055741560 @default.
• W2060602021 cites W2061292791 @default.
• W2060602021 cites W2061728533 @default.
• W2060602021 cites W2063825367 @default.
• W2060602021 cites W2070666617 @default.
• W2060602021 cites W2073998635 @default.
• W2060602021 cites W2075269563 @default.
• W2060602021 cites W2078855906 @default.
• W2060602021 cites W2084131058 @default.
• W2060602021 cites W2087653208 @default.
• W2060602021 cites W2087776711 @default.
• W2060602021 cites W2088551118 @default.
• W2060602021 cites W2090392995 @default.
• W2060602021 cites W2092406843 @default.
• W2060602021 cites W2092579180 @default.
• W2060602021 cites W2098062600 @default.
• W2060602021 cites W2113311041 @default.
• W2060602021 cites W2114245938 @default.
• W2060602021 cites W2117309266 @default.
• W2060602021 cites W2121161144 @default.
• W2060602021 cites W2138483765 @default.
• W2060602021 cites W2140646145 @default.
• W2060602021 cites W2143599482 @default.
• W2060602021 cites W2144954864 @default.
• W2060602021 cites W2150235363 @default.
• W2060602021 cites W2156772263 @default.
• W2060602021 cites W2157443220 @default.
• W2060602021 cites W2168536235 @default.
• W2060602021 cites W4243981469 @default.
• W2060602021 cites W958578800 @default.
• W2060602021 doi "https://doi.org/10.1002/eji.200535247" @default.
• W2060602021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16278813" @default.
• W2060602021 hasPublicationYear "2005" @default.
• W2060602021 type Work @default.
• W2060602021 sameAs 2060602021 @default.
• W2060602021 citedByCount "16" @default.
• W2060602021 countsByYear W20606020212012 @default.
• W2060602021 countsByYear W20606020212013 @default.
• W2060602021 countsByYear W20606020212014 @default.
• W2060602021 countsByYear W20606020212019 @default.
• W2060602021 crossrefType "journal-article" @default.
• W2060602021 hasAuthorship W2060602021A5001353518 @default.
• W2060602021 hasAuthorship W2060602021A5030700291 @default.
• W2060602021 hasAuthorship W2060602021A5042698206 @default.
• W2060602021 hasAuthorship W2060602021A5061788017 @default.
• W2060602021 hasAuthorship W2060602021A5070851567 @default.
• W2060602021 hasAuthorship W2060602021A5075122404 @default.
• W2060602021 hasBestOaLocation W20606020211 @default.
• W2060602021 hasConcept C108636557 @default.
• W2060602021 hasConcept C111700020 @default.
• W2060602021 hasConcept C11960822 @default.
• W2060602021 hasConcept C157695867 @default.
• W2060602021 hasConcept C159654299 @default.
• W2060602021 hasConcept C170493617 @default.
• W2060602021 hasConcept C175818844 @default.
• W2060602021 hasConcept C203014093 @default.
• W2060602021 hasConcept C2778453870 @default.
• W2060602021 hasConcept C43907098 @default.
• W2060602021 hasConcept C502942594 @default.
• W2060602021 hasConcept C54355233 @default.
• W2060602021 hasConcept C86803240 @default.

• next