FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060609416> ?p ?o ?g. }

• W2060609416 endingPage "60" @default.
• W2060609416 startingPage "46" @default.
• W2060609416 abstract "Drug–drug interactions (DDIs) are associated with severe adverse effects that may lead to the patient requiring alternative therapeutics and could ultimately lead to drug withdrawal from the market if they are severe. To prevent the occurrence of DDI in the clinic, experimental systems to evaluate drug interaction have been integrated into the various stages of the drug discovery and development process. A large body of knowledge about DDI has also accumulated through these studies and pharmacovigillence systems. Much of this work to date has focused on the drug metabolizing enzymes such as cytochrome P-450s as well as drug transporters, ion channels and occasionally other proteins. This combined knowledge provides a foundation for a hypothesis-driven in silico approach, using either cheminformatics or physiologically based pharmacokinetics (PK) modeling methods to assess DDI potential. Here we review recent advances in these approaches with emphasis on hypothesis-driven mechanistic models for important protein targets involved in PK-based DDI. Recent efforts with other informatics approaches to detect DDI are highlighted. Besides DDI, we also briefly introduce drug interactions with other substances, such as Traditional Chinese Medicines to illustrate how in silico modeling can be useful in this domain. We also summarize valuable data sources and web-based tools that are available for DDI prediction. We finally explore the challenges we see faced by in silico approaches for predicting DDI and propose future directions to make these computational models more reliable, accurate, and publically accessible." @default.
• W2060609416 created "2016-06-24" @default.
• W2060609416 creator A5053498507 @default.
• W2060609416 creator A5060364374 @default.
• W2060609416 creator A5073973321 @default.
• W2060609416 date "2015-06-01" @default.
• W2060609416 modified "2023-10-12" @default.
• W2060609416 title "In silico methods for predicting drug–drug interactions with cytochrome P-450s, transporters and beyond" @default.
• W2060609416 cites W1711639876 @default.
• W2060609416 cites W1913421412 @default.
• W2060609416 cites W1963568502 @default.
• W2060609416 cites W1966492906 @default.
• W2060609416 cites W1966779916 @default.
• W2060609416 cites W1967989141 @default.
• W2060609416 cites W1971990705 @default.
• W2060609416 cites W1972226553 @default.
• W2060609416 cites W1972320695 @default.
• W2060609416 cites W1973225510 @default.
• W2060609416 cites W1975912619 @default.
• W2060609416 cites W1977791869 @default.
• W2060609416 cites W1980911350 @default.
• W2060609416 cites W1981008233 @default.
• W2060609416 cites W1981873124 @default.
• W2060609416 cites W1982647101 @default.
• W2060609416 cites W1983168442 @default.
• W2060609416 cites W1983304433 @default.
• W2060609416 cites W1984678368 @default.
• W2060609416 cites W1985389474 @default.
• W2060609416 cites W1985588649 @default.
• W2060609416 cites W1986724907 @default.
• W2060609416 cites W1990399577 @default.
• W2060609416 cites W1992475241 @default.
• W2060609416 cites W1995449922 @default.
• W2060609416 cites W1995573780 @default.
• W2060609416 cites W1995803587 @default.
• W2060609416 cites W1997424673 @default.
• W2060609416 cites W1999020087 @default.
• W2060609416 cites W1999021046 @default.
• W2060609416 cites W1999227773 @default.
• W2060609416 cites W1999491936 @default.
• W2060609416 cites W2000189060 @default.
• W2060609416 cites W2000582171 @default.
• W2060609416 cites W2001490808 @default.
• W2060609416 cites W2001565801 @default.
• W2060609416 cites W2003509188 @default.
• W2060609416 cites W2004281677 @default.
• W2060609416 cites W2004424444 @default.
• W2060609416 cites W2005215222 @default.
• W2060609416 cites W2005998697 @default.
• W2060609416 cites W2006905097 @default.
• W2060609416 cites W2007615684 @default.
• W2060609416 cites W2007705439 @default.
• W2060609416 cites W2007921205 @default.
• W2060609416 cites W2008294930 @default.
• W2060609416 cites W2008621428 @default.
• W2060609416 cites W2008785161 @default.
• W2060609416 cites W2009456532 @default.
• W2060609416 cites W2009476878 @default.
• W2060609416 cites W2010392703 @default.
• W2060609416 cites W2012559532 @default.
• W2060609416 cites W2012929832 @default.
• W2060609416 cites W2014858249 @default.
• W2060609416 cites W2016155858 @default.
• W2060609416 cites W2016506481 @default.
• W2060609416 cites W2017016867 @default.
• W2060609416 cites W2017241793 @default.
• W2060609416 cites W2017360618 @default.
• W2060609416 cites W2017881600 @default.
• W2060609416 cites W2019258148 @default.
• W2060609416 cites W2020101239 @default.
• W2060609416 cites W2020242913 @default.
• W2060609416 cites W2020286598 @default.
• W2060609416 cites W2020520400 @default.
• W2060609416 cites W2021920492 @default.
• W2060609416 cites W2024059620 @default.
• W2060609416 cites W2025392760 @default.
• W2060609416 cites W2025565476 @default.
• W2060609416 cites W2026429211 @default.
• W2060609416 cites W2026470547 @default.
• W2060609416 cites W2026778803 @default.
• W2060609416 cites W2027086950 @default.
• W2060609416 cites W2027913934 @default.
• W2060609416 cites W2028232704 @default.
• W2060609416 cites W2030245859 @default.
• W2060609416 cites W2030858498 @default.
• W2060609416 cites W2031449719 @default.
• W2060609416 cites W2033192435 @default.
• W2060609416 cites W2034080889 @default.
• W2060609416 cites W2034459977 @default.
• W2060609416 cites W2035001688 @default.
• W2060609416 cites W2037394923 @default.
• W2060609416 cites W2037705821 @default.
• W2060609416 cites W2037837918 @default.
• W2060609416 cites W2040135138 @default.
• W2060609416 cites W2041024416 @default.
• W2060609416 cites W2041063533 @default.
• W2060609416 cites W2041563460 @default.
• W2060609416 cites W2041610798 @default.

• next