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- W2060619354 abstract "The present study was aimed to investigate the effects of a chronic treatment with the dopamine uptake blocker nomifensine on the in vivo extracellular concentrations of dopamine, acetylcholine, glutamate and GABA in the prefrontal cortex, striatum and nucleus accumbens. Male Wistar rats received intraperitoneal (i.p.) daily injections of nomifensine (10 mg/kg) or saline for 22 days. Microdialysis experiments were performed on days 1, 8, 15 and 22 of treatment to evaluate the effects of the injection of nomifensine or saline. Motor activity of the animals was monitored during microdialysis experiments. Injections of nomifensine increased extracellular concentration of dopamine in striatum and nucleus accumbens, but not in prefrontal cortex. Acetylcholine concentrations in striatum but not in nucleus accumbens were increased by nomifensine on days 15 and 22 of treatment. In prefrontal cortex, nomifensine increased acetylcholine levels without differences among days. No changes were found on glutamate and GABA concentrations in the three areas studied. Injections of nomifensine also increased spontaneous motor activity and stereotyped behaviour without differences among days. These results show that systemic chronic treatment with a dopamine uptake blocker produces differential effects on extracellular concentrations of dopamine and acetylcholine, but not glutamate and GABA, in different areas of the brain." @default.
- W2060619354 created "2016-06-24" @default.
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- W2060619354 date "2008-02-01" @default.
- W2060619354 modified "2023-10-15" @default.
- W2060619354 title "Chronic treatment with a dopamine uptake blocker changes dopamine and acetylcholine but not glutamate and GABA concentrations in prefrontal cortex, striatum and nucleus accumbens of the awake rat" @default.
- W2060619354 cites W1498632927 @default.
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- W2060619354 cites W1608133052 @default.
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- W2060619354 cites W1964775749 @default.
- W2060619354 cites W1976494877 @default.
- W2060619354 cites W1980420429 @default.
- W2060619354 cites W1984853505 @default.
- W2060619354 cites W1986548413 @default.
- W2060619354 cites W1987904398 @default.
- W2060619354 cites W1989151900 @default.
- W2060619354 cites W1990162104 @default.
- W2060619354 cites W1992478337 @default.
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- W2060619354 cites W1994816388 @default.
- W2060619354 cites W1996591405 @default.
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- W2060619354 cites W2006518174 @default.
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- W2060619354 cites W2009752850 @default.
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- W2060619354 cites W2022233762 @default.
- W2060619354 cites W2022395708 @default.
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- W2060619354 cites W2031219969 @default.
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- W2060619354 doi "https://doi.org/10.1016/j.neuint.2007.08.005" @default.
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