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- W2060630994 abstract "Ro 5-4864 is a 1,4 benzodiazepine lacking typical benzodiazepine behavioural actions, and which has very low affinity for the “classical” CNS benzodiazepine binding sites. However, Ro 5-4864 has very high affinity for the peripheral type of binding site in the periphery and in the brain. Evidence is reviewed that Ro 5-4864 is sedative, convulsant and anxiogenic in rodents. We also describe the effects of combining Ro 5-4864 treatment with benzodiazepines (e.g. diazepam, chlordiazepoxide) and with other drugs that modify the activity of benzodiazepines (Ro 15-1788, CGS 8216, picrotoxin, PK 11195, phenytoin). The binding sites that might be mediating these behavioural actions of Ro 5-4864 are discussed." @default.
- W2060630994 created "2016-06-24" @default.
- W2060630994 creator A5009265971 @default.
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- W2060630994 date "1984-07-01" @default.
- W2060630994 modified "2023-10-11" @default.
- W2060630994 title "Behavioural actions of Ro 5-4864: A peripheral-type benzodiazepine?" @default.
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- W2060630994 doi "https://doi.org/10.1016/0024-3205(84)90106-1" @default.
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