Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060641180> ?p ?o ?g. }
- W2060641180 endingPage "707" @default.
- W2060641180 startingPage "695" @default.
- W2060641180 abstract "Background Calcitonin gene-related peptide (CGRP) is a key molecule in migraine pathophysiology. Most studies have focused on CGRP in relation to migraine without aura (MO). About one-third of migraine patients have attacks with aura (MA), and this is a systematic review of the current literature on CGRP and MA. Methods We performed a systematic literature search on MEDLINE for reports of CGRP and MA, covering basic science, animal and human studies as well as randomized clinical trials. Results The literature search identified 594 citations, of which 38 contained relevant, original data. Plasma levels of CGRP in MA patients are comparable to MO, but CGRP levels varied among studies. A number of animal studies, including knock-ins of familial hemiplegic migraine (FHM) genes, have examined the relationship between CGRP and cortical spreading depression. In patients, CGRP does not trigger migraine in FHM, but is a robust trigger of migraine-like headache both in MA and MO patients. The treatment effect of CGRP antagonists are well proven in the treatment of migraine, but no studies have studied the effect specifically in MA patients. Conclusion This systematic review indicates that the role of CGRP in MA is less studied than in MO. Further studies of the importance of CGRP for auras and migraine are needed." @default.
- W2060641180 created "2016-06-24" @default.
- W2060641180 creator A5023775224 @default.
- W2060641180 creator A5071945855 @default.
- W2060641180 date "2014-01-22" @default.
- W2060641180 modified "2023-10-02" @default.
- W2060641180 title "Calcitonin gene-related peptide and migraine with aura: A systematic review" @default.
- W2060641180 cites W100605716 @default.
- W2060641180 cites W1549058410 @default.
- W2060641180 cites W1558431093 @default.
- W2060641180 cites W1559299283 @default.
- W2060641180 cites W1841463848 @default.
- W2060641180 cites W1967478947 @default.
- W2060641180 cites W1967854252 @default.
- W2060641180 cites W1968289417 @default.
- W2060641180 cites W1972550591 @default.
- W2060641180 cites W1972795310 @default.
- W2060641180 cites W1973662774 @default.
- W2060641180 cites W1975937091 @default.
- W2060641180 cites W1976505981 @default.
- W2060641180 cites W1976632666 @default.
- W2060641180 cites W1979959776 @default.
- W2060641180 cites W1982822678 @default.
- W2060641180 cites W1983283512 @default.
- W2060641180 cites W1983300176 @default.
- W2060641180 cites W1987721600 @default.
- W2060641180 cites W1988322670 @default.
- W2060641180 cites W1988706601 @default.
- W2060641180 cites W1989009513 @default.
- W2060641180 cites W1991983514 @default.
- W2060641180 cites W1995092933 @default.
- W2060641180 cites W1996875554 @default.
- W2060641180 cites W1997555942 @default.
- W2060641180 cites W1999147380 @default.
- W2060641180 cites W1999180573 @default.
- W2060641180 cites W2000975819 @default.
- W2060641180 cites W2003587660 @default.
- W2060641180 cites W2004100259 @default.
- W2060641180 cites W2005993198 @default.
- W2060641180 cites W2009450398 @default.
- W2060641180 cites W2009688249 @default.
- W2060641180 cites W2010150274 @default.
- W2060641180 cites W2010648377 @default.
- W2060641180 cites W2011893236 @default.
- W2060641180 cites W2013033676 @default.
- W2060641180 cites W2016499137 @default.
- W2060641180 cites W2018480090 @default.
- W2060641180 cites W2019591295 @default.
- W2060641180 cites W2020317313 @default.
- W2060641180 cites W2023030545 @default.
- W2060641180 cites W2023357588 @default.
- W2060641180 cites W2024556676 @default.
- W2060641180 cites W2026470025 @default.
- W2060641180 cites W2027121504 @default.
- W2060641180 cites W2029611164 @default.
- W2060641180 cites W2031081542 @default.
- W2060641180 cites W2031512838 @default.
- W2060641180 cites W2032976585 @default.
- W2060641180 cites W2033743637 @default.
- W2060641180 cites W2035581625 @default.
- W2060641180 cites W2035672577 @default.
- W2060641180 cites W2036240698 @default.
- W2060641180 cites W2037206898 @default.
- W2060641180 cites W2038078887 @default.
- W2060641180 cites W2038399206 @default.
- W2060641180 cites W2039984694 @default.
- W2060641180 cites W2044177786 @default.
- W2060641180 cites W2047767557 @default.
- W2060641180 cites W2048132386 @default.
- W2060641180 cites W2050373339 @default.
- W2060641180 cites W2052258972 @default.
- W2060641180 cites W2052273235 @default.
- W2060641180 cites W2053277833 @default.
- W2060641180 cites W2053420136 @default.
- W2060641180 cites W2055448024 @default.
- W2060641180 cites W2055541495 @default.
- W2060641180 cites W2058907206 @default.
- W2060641180 cites W2060711158 @default.
- W2060641180 cites W2060949787 @default.
- W2060641180 cites W2062955354 @default.
- W2060641180 cites W2063829584 @default.
- W2060641180 cites W2065782606 @default.
- W2060641180 cites W2066080151 @default.
- W2060641180 cites W2070760046 @default.
- W2060641180 cites W2073492115 @default.
- W2060641180 cites W2073742256 @default.
- W2060641180 cites W2074769175 @default.
- W2060641180 cites W2076160539 @default.
- W2060641180 cites W2077640446 @default.
- W2060641180 cites W2078402149 @default.
- W2060641180 cites W2080360524 @default.
- W2060641180 cites W2082342373 @default.
- W2060641180 cites W2083821823 @default.
- W2060641180 cites W2085595272 @default.
- W2060641180 cites W2087994192 @default.
- W2060641180 cites W2090042998 @default.
- W2060641180 cites W2095111370 @default.
- W2060641180 cites W2095417922 @default.