FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060642012> ?p ?o ?g. }

• W2060642012 endingPage "no" @default.
• W2060642012 startingPage "no" @default.
• W2060642012 abstract "Context Prenatal treatment with dexamethasone to prevent virilization in pregnancies at risk for classical congenital adrenal hyperplasia (CAH) remains controversial. Objective To conduct a systematic review and meta-analyses of studies that evaluated the effects of dexamethasone administration during pregnancies at risk for classical CAH because of 21-hydroxylase deficiency (CYP21A2). Data Sources We searched MEDLINE, EMBASE, and Cochrane CENTRAL from inception through August 2009. Review of reference lists and contact with CAH experts further identified candidate studies. Study Selection Reviewers working independently and in duplicate determined trial eligibility. Eligible studies reported the effects on either foetal or maternal outcomes of dexamethasone administered during pregnancy compared to a control group that did not receive any treatment. Data Extraction Reviewers working independently and in duplicate determined the methodological quality of studies and collected data on patient characteristics, interventions, and outcomes. Data Synthesis We identified only four eligible observational studies (325 pregnancies treated with dexamethasone). The methodological quality of the included studies was overall low. Meta-analysis demonstrates a reduction in foetus virilization measured by Prader score in female foetuses treated with dexamethasone initiated early during pregnancy (weighted mean difference, −2·33, 95% CI, −3·38, −1·27). No deleterious effects of dexamethasone on stillbirths, spontaneous abortions, foetal malformations, neuropsychological or developmental outcomes were found although these data are quite sparse. There was increased oedema and striae in the mothers treated with dexamethasone. There were no data on long-term follow-up of physical and metabolic outcomes in children exposed to dexamethasone. Conclusions The observational nature of the available evidence and the overall small sample size of the whole body of the literature significantly weaken inferences about the benefits and harms of dexamethasone in this setting. Dexamethasone seems to be associated with reduction in foetus virilization without significant maternal or foetal adverse effects. However, this review underscores the current uncertainty and further investigation is clearly needed. The decision about initiating treatment should be based on patients’ values and preferences and requires fully informed and consenting parents." @default.
• W2060642012 created "2016-06-24" @default.
• W2060642012 creator A5018555946 @default.
• W2060642012 creator A5030162181 @default.
• W2060642012 creator A5036456095 @default.
• W2060642012 creator A5036488282 @default.
• W2060642012 creator A5042592297 @default.
• W2060642012 creator A5044253367 @default.
• W2060642012 creator A5054802858 @default.
• W2060642012 creator A5061691563 @default.
• W2060642012 creator A5065694649 @default.
• W2060642012 creator A5066267611 @default.
• W2060642012 creator A5066281606 @default.
• W2060642012 creator A5084537041 @default.
• W2060642012 creator A5091531387 @default.
• W2060642012 date "2010-06-09" @default.
• W2060642012 modified "2023-10-18" @default.
• W2060642012 title "Prenatal Dexamethasone Use For The Prevention Of Virilization In Pregnancies At Risk For Classical Congenital Adrenal Hyperplasia due to 21 hydroxylase (CYP21A2) deficiency: A Systematic Review And Meta-Analyses" @default.
• W2060642012 doi "https://doi.org/10.1111/j.1365-2265.2010.03826.x" @default.
• W2060642012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20550539" @default.
• W2060642012 hasPublicationYear "2010" @default.
• W2060642012 type Work @default.
• W2060642012 sameAs 2060642012 @default.
• W2060642012 citedByCount "47" @default.
• W2060642012 countsByYear W20606420122012 @default.
• W2060642012 countsByYear W20606420122013 @default.
• W2060642012 countsByYear W20606420122014 @default.
• W2060642012 countsByYear W20606420122015 @default.
• W2060642012 countsByYear W20606420122016 @default.
• W2060642012 countsByYear W20606420122017 @default.
• W2060642012 countsByYear W20606420122018 @default.
• W2060642012 countsByYear W20606420122019 @default.
• W2060642012 countsByYear W20606420122021 @default.
• W2060642012 countsByYear W20606420122022 @default.
• W2060642012 countsByYear W20606420122023 @default.
• W2060642012 crossrefType "journal-article" @default.
• W2060642012 hasAuthorship W2060642012A5018555946 @default.
• W2060642012 hasAuthorship W2060642012A5030162181 @default.
• W2060642012 hasAuthorship W2060642012A5036456095 @default.
• W2060642012 hasAuthorship W2060642012A5036488282 @default.
• W2060642012 hasAuthorship W2060642012A5042592297 @default.
• W2060642012 hasAuthorship W2060642012A5044253367 @default.
• W2060642012 hasAuthorship W2060642012A5054802858 @default.
• W2060642012 hasAuthorship W2060642012A5061691563 @default.
• W2060642012 hasAuthorship W2060642012A5065694649 @default.
• W2060642012 hasAuthorship W2060642012A5066267611 @default.
• W2060642012 hasAuthorship W2060642012A5066281606 @default.
• W2060642012 hasAuthorship W2060642012A5084537041 @default.
• W2060642012 hasAuthorship W2060642012A5091531387 @default.
• W2060642012 hasConcept C126322002 @default.
• W2060642012 hasConcept C131872663 @default.
• W2060642012 hasConcept C151730666 @default.
• W2060642012 hasConcept C187212893 @default.
• W2060642012 hasConcept C23131810 @default.
• W2060642012 hasConcept C2776631543 @default.
• W2060642012 hasConcept C2777767042 @default.
• W2060642012 hasConcept C2777911890 @default.
• W2060642012 hasConcept C2779234561 @default.
• W2060642012 hasConcept C2779343474 @default.
• W2060642012 hasConcept C2780401358 @default.
• W2060642012 hasConcept C54355233 @default.
• W2060642012 hasConcept C71315377 @default.
• W2060642012 hasConcept C71924100 @default.
• W2060642012 hasConcept C86803240 @default.
• W2060642012 hasConcept C95190672 @default.
• W2060642012 hasConceptScore W2060642012C126322002 @default.
• W2060642012 hasConceptScore W2060642012C131872663 @default.
• W2060642012 hasConceptScore W2060642012C151730666 @default.
• W2060642012 hasConceptScore W2060642012C187212893 @default.
• W2060642012 hasConceptScore W2060642012C23131810 @default.
• W2060642012 hasConceptScore W2060642012C2776631543 @default.
• W2060642012 hasConceptScore W2060642012C2777767042 @default.
• W2060642012 hasConceptScore W2060642012C2777911890 @default.
• W2060642012 hasConceptScore W2060642012C2779234561 @default.
• W2060642012 hasConceptScore W2060642012C2779343474 @default.
• W2060642012 hasConceptScore W2060642012C2780401358 @default.
• W2060642012 hasConceptScore W2060642012C54355233 @default.
• W2060642012 hasConceptScore W2060642012C71315377 @default.
• W2060642012 hasConceptScore W2060642012C71924100 @default.
• W2060642012 hasConceptScore W2060642012C86803240 @default.
• W2060642012 hasConceptScore W2060642012C95190672 @default.
• W2060642012 hasLocation W20606420121 @default.
• W2060642012 hasLocation W20606420122 @default.
• W2060642012 hasOpenAccess W2060642012 @default.
• W2060642012 hasPrimaryLocation W20606420121 @default.
• W2060642012 hasRelatedWork W118974040 @default.
• W2060642012 hasRelatedWork W1536011726 @default.
• W2060642012 hasRelatedWork W1978234054 @default.
• W2060642012 hasRelatedWork W1990687460 @default.
• W2060642012 hasRelatedWork W2009479165 @default.
• W2060642012 hasRelatedWork W2324760457 @default.
• W2060642012 hasRelatedWork W2332285679 @default.
• W2060642012 hasRelatedWork W2394864040 @default.
• W2060642012 hasRelatedWork W3187967522 @default.
• W2060642012 hasRelatedWork W4226253253 @default.
• W2060642012 isParatext "false" @default.
• W2060642012 isRetracted "false" @default.
• W2060642012 magId "2060642012" @default.

• next