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- W2060642832 abstract "Treatment with the ototoxic antibiotic gentamicin results in specific damage to hair cells of the inner ear and possibly of the lateral line system. In amphibians, damaged hair cells may spontaneously recover. Rana catesbeiana tadpoles were treated with different dosages of gentamicin solution, including a nontreated control, for 24 h. Animals were tested behaviorally and then sacrificed either immediately or after a 7 day recovery period. Their brains were processed for immunohistofluorescent labeling of caspase‐3, a marker for apoptosis. Behavioral changes associated with gentamicin treatment included a disruption of balance, altered swimming, and an inability to detect water currents. Animals treated with gentamicin showed increased caspase‐3 expression in multiple brain areas compared to non‐treated controls. Animals allowed a 7 day recovery period that showed lower caspase‐3 label across brain areas than animals sacrificed immediately after treatment. These results suggest that ototoxic damage is associated with increased caspase‐3 expression in the central nervous system. In tadpoles, affected behaviors undergo spontaneous recovery, which is itself correlated with decreases in caspase‐3 expression. [Work supported by NSF GRFP, NIH, and RI Space Grants.]" @default.
- W2060642832 created "2016-06-24" @default.
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- W2060642832 date "2010-03-01" @default.
- W2060642832 modified "2023-09-26" @default.
- W2060642832 title "Effect of ototoxic drugs on Rana catesbeiana tadpole orientation behavior and caspase‐3 expression." @default.
- W2060642832 doi "https://doi.org/10.1121/1.3385330" @default.
- W2060642832 hasPublicationYear "2010" @default.
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