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- W2060644706 endingPage "1775" @default.
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- W2060644706 abstract "In the vitamin E group, alpha-tocopherol is generally considered to be the most potent antioxidant with the highest vitamin bioactivity, yet gamma-tocopherol is produced in greater amounts by many plants and is the principal tocopherol in the United States diet. This report describes a fundamental difference in the chemical reactivities of alpha-tocopherol and gamma-tocopherol with nitrogen dioxide (NO2), which leads to the formation of a nitrosating agent from alpha-tocopherol, but not from gamma-tocopherol. Nitric oxide (NO) is a major product of the reaction of gamma-tocopherol with NO2, while alpha-tocopherol reacts with NO2 to form an intermediate tocopheroxide analogue. The biological significance of gamma-tocopherol is suggested by limited epidemiological data as well as the observation that it is a more potent inhibitor than alpha-tocopherol of neoplastic transformation during the postinitiation phase in 3-methylcholanthrene-treated C3H/10T1/2 murine fibroblasts. This latter property suggests the superiority of gamma-tocopherol in a mammalian biological assay and a role for endogenous NO production in promotion of neoplastic transformation." @default.
- W2060644706 created "2016-06-24" @default.
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- W2060644706 date "1993-03-01" @default.
- W2060644706 modified "2023-10-17" @default.
- W2060644706 title "Gamma-tocopherol detoxification of nitrogen dioxide: superiority to alpha-tocopherol." @default.
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- W2060644706 doi "https://doi.org/10.1073/pnas.90.5.1771" @default.
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