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• W2060647389 endingPage "1991" @default.
• W2060647389 startingPage "1984" @default.
• W2060647389 abstract "According to a classic tenet, sugar transport across animal membranes is restricted to monosaccharides. Here, we present the first report of an animal sucrose transporter, SCRT, which we detected in Drosophila melanogaster at each developmental stage. We localized the protein in apical membranes of the late embryonic hindgut as well as in vesicular membranes of ovarian follicle cells. The fact that knockdown of SCRT expression results in significantly increased lethality demonstrates an essential function for the protein. Experiments with Saccharomyces cerevisiae as a heterologous expression system revealed that sucrose is a transported substrate. Because the knockout of SLC45A2, a highly similar protein belonging to the mammalian solute carrier family 45 (SLC45) causes oculocutaneous albinism and because the vesicular structures in which SCRT is located appear to contain melanin, we propose that these organelles are melanosome-like structures and that the transporter is necessary for balancing the osmotic equilibrium during the polymerization process of melanin by the import of a compatible osmolyte. In the hindgut epithelial cells, sucrose might also serve as a compatible osmolyte, but we cannot exclude the possibility that transport of this disaccharide also serves nutritional adequacy." @default.
• W2060647389 created "2016-06-24" @default.
• W2060647389 creator A5047645771 @default.
• W2060647389 creator A5054596824 @default.
• W2060647389 creator A5066946579 @default.
• W2060647389 date "2011-06-15" @default.
• W2060647389 modified "2023-10-15" @default.
• W2060647389 title "Identification of an animal sucrose transporter" @default.
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• W2060647389 doi "https://doi.org/10.1242/jcs.082024" @default.
• W2060647389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21586609" @default.
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