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- W2060649852 abstract "Netrins are a family of secreted proteins that function as axon guidance cues during neural development. High levels of netrin-1 expressed by the embryonic ganglionic eminence, the precursor of the adult striatum, direct axons that pioneer the internal capsule. Here we describe netrin-1 expression by neurons distributed throughout the striatum of the adult mouse. Differences were detected in the number and type of neurons expressing netrin-1 in different regions of the striatum. Most neurons in the ventral striatum, including projection neurons and cholinergic interneurons, express netrin-1. In contrast, netrin-1 expression is largely limited to cholinergic interneurons in the dorsal striatum, and the proportion of cholinergic interneurons that express netrin-1 decreases along rostral–caudal and ventral–dorsal axes. Regional differences in expression in the adult striatum suggest that netrin-1 not only influences the development of striatal circuitry but may also participate in the maintenance and plasticity of connections in the adult brain." @default.
- W2060649852 created "2016-06-24" @default.
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- W2060649852 date "2008-12-01" @default.
- W2060649852 modified "2023-09-24" @default.
- W2060649852 title "Graded expression of netrin-1 by specific neuronal subtypes in the adult mammalian striatum" @default.
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- W2060649852 doi "https://doi.org/10.1016/j.neuroscience.2008.09.031" @default.
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