Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060659318> ?p ?o ?g. }
- W2060659318 endingPage "533" @default.
- W2060659318 startingPage "527" @default.
- W2060659318 abstract "When tissue is destroyed, pain arises. Tissue destruction is associated with an inflammatory reaction. This leads to activation of nociceptors. The following review will concentrate on pro-algesic and analgesic mediators, which arise from immune cells or resident cells in the periphery or the circulation during inflammation.In early inflammation endogenous hyperalgesic mediators are produced, including cytokines, chemokines, nerve growth factor as well as bradykinin, prostaglandins and ATP. Simultaneously, analgesic mediators are secreted: opioid peptides, somatostatin, endocannabinoids and certain cytokines. Inflammation increases the expression of peripheral opioid receptors on sensory nerve terminals and enhances their signal transduction, as well as the amount of opioid peptides in infiltrating immune cells. Interference with the recruitment of opioid-containing immune cells into inflamed tissue by blockade of adhesion molecules or by intrathecal morphine injection reduces endogenous analgesia.Inflammatory pain is the result of the interplay between pro-algesic and analgesic mediators. To avoid central side effects, future analgesic therapy should be targeted at either selectively blocking novel pro-algesic mediators or at enhancing endogenous peripheral analgesic effects." @default.
- W2060659318 created "2016-06-24" @default.
- W2060659318 creator A5026424123 @default.
- W2060659318 creator A5029815326 @default.
- W2060659318 creator A5039989749 @default.
- W2060659318 date "2003-10-01" @default.
- W2060659318 modified "2023-10-02" @default.
- W2060659318 title "Pro-algesic versus analgesic actions of immune cells" @default.
- W2060659318 cites W1523062047 @default.
- W2060659318 cites W1528778201 @default.
- W2060659318 cites W1614380970 @default.
- W2060659318 cites W1623121663 @default.
- W2060659318 cites W1661652663 @default.
- W2060659318 cites W1862246641 @default.
- W2060659318 cites W1883044208 @default.
- W2060659318 cites W1904734022 @default.
- W2060659318 cites W1938231026 @default.
- W2060659318 cites W1963760749 @default.
- W2060659318 cites W1963857381 @default.
- W2060659318 cites W1965009971 @default.
- W2060659318 cites W1967008947 @default.
- W2060659318 cites W1968172003 @default.
- W2060659318 cites W1968618759 @default.
- W2060659318 cites W1968714225 @default.
- W2060659318 cites W1969845682 @default.
- W2060659318 cites W1975423956 @default.
- W2060659318 cites W1978286026 @default.
- W2060659318 cites W1981729318 @default.
- W2060659318 cites W1984632338 @default.
- W2060659318 cites W1988512128 @default.
- W2060659318 cites W1988585965 @default.
- W2060659318 cites W1989221461 @default.
- W2060659318 cites W1995705528 @default.
- W2060659318 cites W1999808927 @default.
- W2060659318 cites W2004733357 @default.
- W2060659318 cites W2010909471 @default.
- W2060659318 cites W2014955407 @default.
- W2060659318 cites W2015395924 @default.
- W2060659318 cites W2019965219 @default.
- W2060659318 cites W2027868607 @default.
- W2060659318 cites W2030204659 @default.
- W2060659318 cites W2033417908 @default.
- W2060659318 cites W2035527336 @default.
- W2060659318 cites W2037044386 @default.
- W2060659318 cites W2039947092 @default.
- W2060659318 cites W2040035374 @default.
- W2060659318 cites W2041136179 @default.
- W2060659318 cites W2044202768 @default.
- W2060659318 cites W2045066603 @default.
- W2060659318 cites W2047142489 @default.
- W2060659318 cites W2056416370 @default.
- W2060659318 cites W2059730682 @default.
- W2060659318 cites W2061099467 @default.
- W2060659318 cites W2062379760 @default.
- W2060659318 cites W2072369247 @default.
- W2060659318 cites W2079076998 @default.
- W2060659318 cites W2079912778 @default.
- W2060659318 cites W2082445626 @default.
- W2060659318 cites W2084656370 @default.
- W2060659318 cites W2093580810 @default.
- W2060659318 cites W2094835720 @default.
- W2060659318 cites W2101203355 @default.
- W2060659318 cites W2114688563 @default.
- W2060659318 cites W2118283115 @default.
- W2060659318 cites W2125918623 @default.
- W2060659318 cites W2140784741 @default.
- W2060659318 cites W2150033209 @default.
- W2060659318 cites W2151975160 @default.
- W2060659318 cites W2152593585 @default.
- W2060659318 cites W2160876060 @default.
- W2060659318 cites W2163547524 @default.
- W2060659318 cites W2171584675 @default.
- W2060659318 cites W2171717653 @default.
- W2060659318 doi "https://doi.org/10.1097/00001503-200310000-00014" @default.
- W2060659318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17021507" @default.
- W2060659318 hasPublicationYear "2003" @default.
- W2060659318 type Work @default.
- W2060659318 sameAs 2060659318 @default.
- W2060659318 citedByCount "26" @default.
- W2060659318 countsByYear W20606593182012 @default.
- W2060659318 countsByYear W20606593182013 @default.
- W2060659318 countsByYear W20606593182014 @default.
- W2060659318 countsByYear W20606593182015 @default.
- W2060659318 countsByYear W20606593182017 @default.
- W2060659318 countsByYear W20606593182019 @default.
- W2060659318 countsByYear W20606593182022 @default.
- W2060659318 countsByYear W20606593182023 @default.
- W2060659318 crossrefType "journal-article" @default.
- W2060659318 hasAuthorship W2060659318A5026424123 @default.
- W2060659318 hasAuthorship W2060659318A5029815326 @default.
- W2060659318 hasAuthorship W2060659318A5039989749 @default.
- W2060659318 hasConcept C118303440 @default.
- W2060659318 hasConcept C126322002 @default.
- W2060659318 hasConcept C13373296 @default.
- W2060659318 hasConcept C15490471 @default.
- W2060659318 hasConcept C16613235 @default.
- W2060659318 hasConcept C170493617 @default.
- W2060659318 hasConcept C172659308 @default.