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- W2060672694 abstract "Interleukin (IL-35) is a newly identified heterodimeric cytokine belonging to the IL-12 family. It contains Epstein-Barr virus-induced gene 3 subunit and IL-27 p35 subunit. Although its receptor and signaling pathway are not clear, we presumed that its receptor is composed by two chains that might be similar to those receptors of IL-12, IL-23, and IL-27. We also believe that the signal transducer activator of transcription family members is involved in its signaling pathway. It was reported that IL-35 could suppress Teff cell proliferation and Th17 development. It was considered to have a potential therapeutic effect against immune diseases. In our perspective, the finding of IL-35 is of great significance, since it can regulate T cells, which is an important therapeutic target of immunological disorders. IL-35 would promote the development of different kinds of vaccines, even vaccine for special cancer, and be promising to cure autoimmune and inflammatory diseases." @default.
- W2060672694 created "2016-06-24" @default.
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- W2060672694 creator A5062460409 @default.
- W2060672694 creator A5087100048 @default.
- W2060672694 date "2013-06-01" @default.
- W2060672694 modified "2023-10-16" @default.
- W2060672694 title "Interleukin-35: The Future of Hyperimmune-Related Diseases?" @default.
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- W2060672694 doi "https://doi.org/10.1089/jir.2012.0086" @default.
- W2060672694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23472662" @default.
- W2060672694 hasPublicationYear "2013" @default.
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