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- W2060675874 abstract "The finding that low plasma VEGF165b (vascular endothelial growth factor) in the first trimester is a predictive marker for pre-eclampsia [1] is very interesting. Although aspirin therapy was suggested as an appropriate response if plasma VEGF165b is low, there is a significant risk of gastrointestinal tract bleeding from aspirin.A risk factor for pre-eclampsia is low serum 25(OH)D (25-hydroxyvitamin D). In a nested case-control study of pregnant women followed from less than 16 weeks of gestation to delivery, a 20 ng/ml decline in 25(OH)D increased the risk of pre-eclampsia to an adjusted odds ratio of 2.4 (95% confidence interval, 1.1–5.4) [2]. On the basis of this observation, a search of Pubmed for papers reporting an effect of vitamin D on VEGF was done, revealing several such reports, for example Cardus et al. [3].It has been suggested that pregnant and lactating women require 4000–6000 international units/day of vitamin D [4]. As VEGF tests are much more expensive than vitamin D supplements and since there are many health benefits of vitamin D, including protection against many types of cancer, cardiovascular diseases, bacterial and viral infections, bone diseases and diabetes [5], as well as induction of gene expression of hundreds-to-thousands of genes [6], increasing serum 25(OH) through vitamin D supplementation or production from UV-B irradiance would be preferred to routine testing for serum VEGF levels. A small programme could be conducted to verify that increased serum 25(OH)D during pregnancy increases VEGF and reduces the risk of pre-eclampsia. Other benefits, such as reduced risk of maternal infectious disease and a healthier infant at time of delivery, could also be sought.W. B. G. receives funding from the UV Foundation (McLean, VA, U.S.A.) and the European Sunlight Association (Brussels, Belgium)." @default.
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- W2060675874 date "2009-05-14" @default.
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- W2060675874 title "Role of vitamin D in up-regulating VEGF and reducing the risk of pre-eclampsia" @default.
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- W2060675874 doi "https://doi.org/10.1042/cs20080562" @default.
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