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• W2060679219 startingPage "89" @default.
• W2060679219 abstract "Testicular function, specifically, production of testosterone by Leydig cells, diminishes during aging. Estradiol is also produced by the testis and potentially acts in an autocrine or paracrine manner to help regulate spermatogenesis. However, changes in estradiol concentration or receptor expression within the testis during aging remain unclear. This study was designed to test the hypothesis that the estrogen environment of the testis is altered during aging and that these changes are associated with declining sperm production. Sprague Dawley rats were examined at three, 15, 18, and 21 months of age to detail changes in sperm production and testicular concentration of testosterone and estradiol; five rats were used at three and 21 months and three rats were used at 15 and 18 months. Daily sperm production declined 49% from 15 to 21 months of age. Testicular concentrations of estradiol declined 53% from 15 to 21 months of age; testosterone concentrations were not significantly different. These results suggest that declines in intra-testicular estradiol may contribute to declining sperm production. We further tested our hypothesis by treating rats once every third day with a subcutaneous injection of estradiol valerate (1 µg/kg) from 15 to 18 months of age. Estradiol was increased 54% in treated animals while testosterone was unaffected. Estrogen receptor alpha (ESR1) expression was significantly reduced from 15 to 18 months and expression in estrogen-treated animals was significantly higher than age-matched controls. Additionally, ESR1 expression in 18 month treated animals was not different from 15 months of age. Importantly, daily sperm production in 18 month treated animals was 22% higher than age-matched controls; thus, treatment prevented approximately half of the decline observed in control animals. Collectively, our results suggest that estrogen is involved in maintaining optimum spermatogenesis in adult rats and that estrogen treatment may attenuate the age-associated loss in sperm production." @default.
• W2060679219 created "2016-06-24" @default.
• W2060679219 creator A5026078400 @default.
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• W2060679219 date "2014-02-05" @default.
• W2060679219 modified "2023-09-23" @default.
• W2060679219 title "Alterations in the estrogen environment of the testis contribute to declining sperm production in aging rats" @default.
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• W2060679219 doi "https://doi.org/10.3109/19396368.2014.885995" @default.
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