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• W2060691844 abstract "Estrogen receptor (ER) antagonists have been widely used for breast cancer treatment, but the efficacy and drug resistance remain to be clinical concerns. The purpose of this study was to determine whether the extracts of coptis, an anti-inflammatory herb, improve the anticancer efficacy of ER antagonists. The results showed that the combined treatment of ER antagonists and the crude extract of coptis or its purified compound berberine conferred synergistic growth inhibitory effect on MCF-7 cells (ER+), but not on MDA-MB-231 cells (ER-). Similar results were observed in the combined treatment of fulvestrant, a specific aromatase antagonist. Analysis of the expression of breast cancer related genes indicated that EGFR, HER2, bcl-2, and COX-2 were significantly downregulated, while IFN-beta and p21 were remarkably upregulated by berberine. Our results suggest that coptis extracts could be promising adjuvant to ER antagonists in ER positive breast cancer treatment through regulating expression of multiple genes." @default.
• W2060691844 created "2016-06-24" @default.
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• W2060691844 date "2009-01-01" @default.
• W2060691844 modified "2023-09-30" @default.
• W2060691844 title "Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cells" @default.
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• W2060691844 doi "https://doi.org/10.1016/j.bbrc.2008.10.169" @default.
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