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- W2060694810 abstract "Unfractionated heparin is usually obtained from one of two sources: porcine gut or bovine lung. Comparative studies performed in the 1970s of medical patients receiving pork or beef heparin found a much higher frequency of thrombocytopenia in patients who received the beef heparin preparation [1, 2]. However, these studies included all episodes of thrombocytopenia and did not focus on the important patient subgroup with late thrombocytopenia, beginning on or after day 5 of heparin, caused by heparin-dependent, plateletactivating antibodies. Indeed, this syndrome of immune heparin-induced thrombocytopenia (HIT) presents a paradox of anticoagulant-induced thrombosis, as patients with HIT are at high risk for developing venous or arterial thrombosis [3]. During the 1980s, four randomized trials [4 –7] were performed that compared the frequency of immune HIT in patients receiving either pork and beef heparin for treatment of acute thrombosis. Although each study was fairly small, their combined results left little doubt that bovine lung heparin was more likely to cause immune HIT: 9 of 152 (5.9%) versus 0 of 154 (0%) patients (p" @default.
- W2060694810 created "2016-06-24" @default.
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- W2060694810 date "2003-01-01" @default.
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- W2060694810 title "Pork or beef?" @default.
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- W2060694810 doi "https://doi.org/10.1016/s0003-4975(02)04017-1" @default.
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