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- W2060699006 abstract "The observation that baclofen stimulates growth hormone (GH) secretion in normal men, but not in parkinsonian patients led us to test the GH releasing effect of other γ-amino-butyric acid (GABA)ergic agents with different mechanisms of action in Parkinson's disease. For this purpose 10 normal men and 10 de novo parkinsonian patients were tested with sodium valproate (800 mg PO), γ-hydroxybutyric acid (GHB) (25 mg/kg body weight PO) and baclofen (10 mg PO). All drugs induced a significant increment in serum GH levels in the normal controls. On the other hand, GH secretion in parkinsonian patients did not change after baclofen or sodium valproate administration, whereas it showed normal responsiveness to GHB. These data suggest that the mechanism underlying the GH response to GHB is different from that (or those) mediating sodium valproate and/or baclofen action. In addition, the former, but not the latter mechanism appears to be preserved in the parkinsonian brain." @default.
- W2060699006 created "2016-06-24" @default.
- W2060699006 creator A5023867133 @default.
- W2060699006 creator A5040777286 @default.
- W2060699006 creator A5041473360 @default.
- W2060699006 creator A5090443303 @default.
- W2060699006 date "1982-01-01" @default.
- W2060699006 modified "2023-09-26" @default.
- W2060699006 title "Regulatory role of gamma-aminobutyric acid in pituitary hormone secretion" @default.
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