FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060702961> ?p ?o ?g. }

• W2060702961 endingPage "123" @default.
• W2060702961 startingPage "112" @default.
• W2060702961 abstract "D1-like dopamine receptors stimulate Ca2+ transients in neurons but the effector coupling and signaling mechanisms underlying these responses have not been elucidated. Here we investigated potential mechanisms using both HEK 293 cells that stably express D1 receptors (D1HEK293) and hippocampal neurons in culture. In D1HEK293 cells, the full D1 receptor agonist SKF 81297 evoked a robust dose-dependent increase in Ca2+i following ‘priming’ of endogenous Gq/11-coupled muscarinic or purinergic receptors. The effect of SKF81297 could be mimicked by forskolin or 8-Br-cAMP. Further, cholera toxin and the cAMP-dependent protein kinase (PKA) inhibitors, KT5720 and H89, as well as thapsigargin abrogated the D1 receptor evoked Ca2+ transients. Removal of the priming agonist and treatment with the phospholipase C inhibitor U73122 also blocked the SKF81297-evoked responses. D1R agonist did not stimulate IP3 production, but pretreatment of cells with the D1R agonist potentiated Gq-linked receptor agonist mobilization of intracellular Ca2+ stores. In neurons, SKF81297 and SKF83959, a partial D1 receptor agonist, promoted Ca2+ oscillations in response to Gq/11-coupled metabotropic glutamate receptor (mGluR) stimulation. The effects of both D1R agonists on the mGluR-evoked Ca2+ responses were PKA dependent. Altogether the data suggest that dopamine D1R activation and ensuing cAMP production dynamically regulates the efficiency and timing of IP3-mediated intracellular Ca2+ store mobilization." @default.
• W2060702961 created "2016-06-24" @default.
• W2060702961 creator A5042044088 @default.
• W2060702961 creator A5048902592 @default.
• W2060702961 creator A5053375725 @default.
• W2060702961 creator A5083487630 @default.
• W2060702961 date "2008-01-01" @default.
• W2060702961 modified "2023-09-24" @default.
• W2060702961 title "A Crucial Role for cAMP and Protein Kinase A in D1 Dopamine Receptor Regulated Intracellular Calcium Transients" @default.
• W2060702961 cites W1483170893 @default.
• W2060702961 cites W1492821183 @default.
• W2060702961 cites W1494195183 @default.
• W2060702961 cites W1536787393 @default.
• W2060702961 cites W1604228477 @default.
• W2060702961 cites W1612007229 @default.
• W2060702961 cites W1650401181 @default.
• W2060702961 cites W1659384861 @default.
• W2060702961 cites W1663699868 @default.
• W2060702961 cites W1782902465 @default.
• W2060702961 cites W1925492557 @default.
• W2060702961 cites W1975108009 @default.
• W2060702961 cites W1991476318 @default.
• W2060702961 cites W1998051122 @default.
• W2060702961 cites W1998442807 @default.
• W2060702961 cites W2006442989 @default.
• W2060702961 cites W2009770052 @default.
• W2060702961 cites W2014278192 @default.
• W2060702961 cites W2035786682 @default.
• W2060702961 cites W2038300112 @default.
• W2060702961 cites W2039482493 @default.
• W2060702961 cites W2043001547 @default.
• W2060702961 cites W2046696038 @default.
• W2060702961 cites W2052981250 @default.
• W2060702961 cites W2058861807 @default.
• W2060702961 cites W2064226140 @default.
• W2060702961 cites W2064693834 @default.
• W2060702961 cites W2067742161 @default.
• W2060702961 cites W2074852535 @default.
• W2060702961 cites W2077240370 @default.
• W2060702961 cites W2084329849 @default.
• W2060702961 cites W2084530213 @default.
• W2060702961 cites W2086015992 @default.
• W2060702961 cites W2089864294 @default.
• W2060702961 cites W2092752023 @default.
• W2060702961 cites W2092928995 @default.
• W2060702961 cites W2102509567 @default.
• W2060702961 cites W2106719141 @default.
• W2060702961 cites W2115110251 @default.
• W2060702961 cites W2119100472 @default.
• W2060702961 cites W2119523770 @default.
• W2060702961 cites W2120297430 @default.
• W2060702961 cites W2122836762 @default.
• W2060702961 cites W2128574573 @default.
• W2060702961 cites W2135710749 @default.
• W2060702961 cites W2136268185 @default.
• W2060702961 cites W2137165188 @default.
• W2060702961 cites W2143843444 @default.
• W2060702961 cites W2154100802 @default.
• W2060702961 cites W2163191890 @default.
• W2060702961 cites W2165292955 @default.
• W2060702961 cites W2220486443 @default.
• W2060702961 cites W2237003845 @default.
• W2060702961 doi "https://doi.org/10.1159/000111557" @default.
• W2060702961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18253052" @default.
• W2060702961 hasPublicationYear "2008" @default.
• W2060702961 type Work @default.
• W2060702961 sameAs 2060702961 @default.
• W2060702961 citedByCount "31" @default.
• W2060702961 countsByYear W20607029612012 @default.
• W2060702961 countsByYear W20607029612013 @default.
• W2060702961 countsByYear W20607029612014 @default.
• W2060702961 countsByYear W20607029612015 @default.
• W2060702961 countsByYear W20607029612017 @default.
• W2060702961 countsByYear W20607029612019 @default.
• W2060702961 countsByYear W20607029612020 @default.
• W2060702961 countsByYear W20607029612022 @default.
• W2060702961 countsByYear W20607029612023 @default.
• W2060702961 crossrefType "journal-article" @default.
• W2060702961 hasAuthorship W2060702961A5042044088 @default.
• W2060702961 hasAuthorship W2060702961A5048902592 @default.
• W2060702961 hasAuthorship W2060702961A5053375725 @default.
• W2060702961 hasAuthorship W2060702961A5083487630 @default.
• W2060702961 hasBestOaLocation W20607029611 @default.
• W2060702961 hasConcept C120750228 @default.
• W2060702961 hasConcept C126322002 @default.
• W2060702961 hasConcept C134018914 @default.
• W2060702961 hasConcept C160262196 @default.
• W2060702961 hasConcept C170493617 @default.
• W2060702961 hasConcept C185592680 @default.
• W2060702961 hasConcept C26702167 @default.
• W2060702961 hasConcept C2778938600 @default.
• W2060702961 hasConcept C49051014 @default.
• W2060702961 hasConcept C55493867 @default.
• W2060702961 hasConcept C71924100 @default.
• W2060702961 hasConcept C86803240 @default.
• W2060702961 hasConcept C95444343 @default.
• W2060702961 hasConceptScore W2060702961C120750228 @default.
• W2060702961 hasConceptScore W2060702961C126322002 @default.

• next