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• W2060712874 abstract "Prestin is a member of the SLC26 family of anion transporters that is responsible for outer hair cell (OHC) electromotility. Measures of voltage-evoked charge density (Q(sp)) of prestin indicated that the protein is highly expressed in OHCs, with single cells expressing up to 10 million molecules within the lateral membrane. In contrast, charge density measures in transfected cells indicated that they express, at best, only a fifth as many proteins on their surface. We sought to determine whether associations with other OHC-specific proteins could account for this difference. Using a yeast two-hybrid technique, we found microtubule-associated protein 1S (MAP1S) bound to prestin. The interaction was limited to the STAS domain of prestin and the region connecting the heavy and light chain of MAP1S. Using reciprocal immunoprecipitation and Forster resonance energy transfer, we confirmed these interactions. Furthermore, co-expression of prestin with MAP1S resulted in a 2.7-fold increase in Q(sp) in single cells that was paralleled by a 2.8-fold increase in protein surface expression, indicating that the interactions are physiological. Quantitative PCR data showed gradients in the expression of prestin and MAP1S across the tonotopic axis that may partially contribute to a previously observed 6-fold increase in Q(sp) in high frequency hair cells. These data highlight the importance of protein partner effects on prestin." @default.
• W2060712874 created "2016-06-24" @default.
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• W2060712874 date "2010-07-01" @default.
• W2060712874 modified "2023-10-01" @default.
• W2060712874 title "Prestin Surface Expression and Activity Are Augmented by Interaction with MAP1S, a Microtubule-associated Protein" @default.
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• W2060712874 doi "https://doi.org/10.1074/jbc.m110.117853" @default.
• W2060712874 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2898336" @default.
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