FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060713034> ?p ?o ?g. }

• W2060713034 endingPage "17016" @default.
• W2060713034 startingPage "17011" @default.
• W2060713034 abstract "Excessive inhibition of brain neurons in primary or slice cultures can induce homeostatic intrinsic plasticity, but the functional role and underlying molecular mechanisms of such plasticity are poorly understood. Here, we developed an ex vivo locus coeruleus (LC) slice culture system and successfully recapitulated the opiate-induced homeostatic adaptation in electrical activity of LC neurons seen in vivo. We investigated the mechanisms underlying this adaptation in LC slice cultures by use of viral-mediated gene transfer and genetic mutant mice. We found that short-term morphine treatment of slice cultures almost completely abolished the firing of LC neurons, whereas chronic morphine treatment increased LC neuronal excitability as revealed during withdrawal. This increased excitability was mediated by direct activation of opioid receptors and up-regulation of the cAMP pathway and accompanied by increased cAMP response-element binding protein (CREB) activity. Overexpression of a dominant negative CREB mutant blocked the increase in LC excitability induced by morphine- or cAMP-pathway activation. Knockdown of CREB in slice cultures from floxed CREB mice similarly decreased LC excitability. Furthermore, the ability of morphine or CREB overexpression to up-regulate LC firing was blocked by knockout of the CREB target adenylyl cyclase 8. Together, these findings provide direct evidence that prolonged exposure to morphine induces homeostatic plasticity intrinsic to LC neurons, involving up-regulation of the cAMP-CREB signaling pathway, which then enhances LC neuronal excitability." @default.
• W2060713034 created "2016-06-24" @default.
• W2060713034 creator A5018192095 @default.
• W2060713034 creator A5024731941 @default.
• W2060713034 creator A5031915521 @default.
• W2060713034 creator A5049993782 @default.
• W2060713034 creator A5063861942 @default.
• W2060713034 creator A5064595778 @default.
• W2060713034 creator A5084260138 @default.
• W2060713034 creator A5084569687 @default.
• W2060713034 date "2010-09-13" @default.
• W2060713034 modified "2023-10-15" @default.
• W2060713034 title "Essential role of the cAMP-cAMP response-element binding protein pathway in opiate-induced homeostatic adaptations of locus coeruleus neurons" @default.
• W2060713034 cites W1482683088 @default.
• W2060713034 cites W1564392853 @default.
• W2060713034 cites W1635719627 @default.
• W2060713034 cites W1646063119 @default.
• W2060713034 cites W1679585809 @default.
• W2060713034 cites W1710482752 @default.
• W2060713034 cites W1902330701 @default.
• W2060713034 cites W1961046454 @default.
• W2060713034 cites W1966425023 @default.
• W2060713034 cites W1981891173 @default.
• W2060713034 cites W1982670370 @default.
• W2060713034 cites W1983158636 @default.
• W2060713034 cites W1992119978 @default.
• W2060713034 cites W2001263497 @default.
• W2060713034 cites W2002252799 @default.
• W2060713034 cites W2012855349 @default.
• W2060713034 cites W2032815047 @default.
• W2060713034 cites W2032997748 @default.
• W2060713034 cites W2035204516 @default.
• W2060713034 cites W2044383729 @default.
• W2060713034 cites W2057855503 @default.
• W2060713034 cites W2067049451 @default.
• W2060713034 cites W2076902628 @default.
• W2060713034 cites W2077956645 @default.
• W2060713034 cites W2079054696 @default.
• W2060713034 cites W2092206787 @default.
• W2060713034 cites W2101465420 @default.
• W2060713034 cites W2104568075 @default.
• W2060713034 cites W2113983630 @default.
• W2060713034 cites W2125834587 @default.
• W2060713034 cites W2136040261 @default.
• W2060713034 cites W2149823377 @default.
• W2060713034 cites W2152268051 @default.
• W2060713034 cites W2161016797 @default.
• W2060713034 cites W2165498557 @default.
• W2060713034 cites W2172734677 @default.
• W2060713034 cites W2222436615 @default.
• W2060713034 cites W2423322041 @default.
• W2060713034 doi "https://doi.org/10.1073/pnas.1010077107" @default.
• W2060713034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2947876" @default.
• W2060713034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20837544" @default.
• W2060713034 hasPublicationYear "2010" @default.
• W2060713034 type Work @default.
• W2060713034 sameAs 2060713034 @default.
• W2060713034 citedByCount "54" @default.
• W2060713034 countsByYear W20607130342012 @default.
• W2060713034 countsByYear W20607130342013 @default.
• W2060713034 countsByYear W20607130342014 @default.
• W2060713034 countsByYear W20607130342015 @default.
• W2060713034 countsByYear W20607130342016 @default.
• W2060713034 countsByYear W20607130342017 @default.
• W2060713034 countsByYear W20607130342018 @default.
• W2060713034 countsByYear W20607130342019 @default.
• W2060713034 countsByYear W20607130342020 @default.
• W2060713034 countsByYear W20607130342021 @default.
• W2060713034 countsByYear W20607130342022 @default.
• W2060713034 countsByYear W20607130342023 @default.
• W2060713034 crossrefType "journal-article" @default.
• W2060713034 hasAuthorship W2060713034A5018192095 @default.
• W2060713034 hasAuthorship W2060713034A5024731941 @default.
• W2060713034 hasAuthorship W2060713034A5031915521 @default.
• W2060713034 hasAuthorship W2060713034A5049993782 @default.
• W2060713034 hasAuthorship W2060713034A5063861942 @default.
• W2060713034 hasAuthorship W2060713034A5064595778 @default.
• W2060713034 hasAuthorship W2060713034A5084260138 @default.
• W2060713034 hasAuthorship W2060713034A5084569687 @default.
• W2060713034 hasBestOaLocation W20607130341 @default.
• W2060713034 hasConcept C104317684 @default.
• W2060713034 hasConcept C115466790 @default.
• W2060713034 hasConcept C1629964 @default.
• W2060713034 hasConcept C169760540 @default.
• W2060713034 hasConcept C170493617 @default.
• W2060713034 hasConcept C173396325 @default.
• W2060713034 hasConcept C185592680 @default.
• W2060713034 hasConcept C2778140631 @default.
• W2060713034 hasConcept C2778468602 @default.
• W2060713034 hasConcept C2779178603 @default.
• W2060713034 hasConcept C2909511254 @default.
• W2060713034 hasConcept C529278444 @default.
• W2060713034 hasConcept C55493867 @default.
• W2060713034 hasConcept C62478195 @default.
• W2060713034 hasConcept C86339819 @default.
• W2060713034 hasConcept C86803240 @default.
• W2060713034 hasConcept C95444343 @default.
• W2060713034 hasConceptScore W2060713034C104317684 @default.

• next