FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060720121> ?p ?o ?g. }

• W2060720121 endingPage "418" @default.
• W2060720121 startingPage "409" @default.
• W2060720121 abstract "Abstract Azoxymethane (AOM) administration to F344 male rats is a widely used model of human colon carcinogenesis. The current study investigates quantitatively the accumulation of K‐ Ras codon 12 mutations following AOM exposure. Male, 6‐week‐old F344 rats were treated subcutaneously with 30 mg/kg body weight of AOM, and colon tissue was collected at 1, 8, 24, and 32 weeks after treatment. The K‐ Ras codon 12 GGT to GAT and GGT to GTT mutant fractions (MFs) were measured using allele‐specific competitive blocker polymerase chain reaction (ACB‐PCR). Between 1 and 32 weeks after AOM treatment, the K‐ Ras codon 12 GGT to GAT geometric mean MF in the rat colon increased significantly from 12.9 × 10 −5 to 145 × 10 −5 , and the GGT to GTT geometric mean MF increased significantly from 5.26 × 10 −5 to 180 × 10 −5 . K‐ Ras codon 12 GGT to GAT MF also increased significantly in AOM‐treated rat colon tissue at 1 week compared to controls (4.44 × 10 −5 ). The accumulation of the GGT to GAT MF long after the DNA adduct repair phase suggests that a portion of cells containing this mutation have a proliferative advantage, allowing them to accumulate as nascent tumors progress. Also, the GGT to GAT background MF increased in untreated rats, indicating that there is accumulation with age. The ACB–PCR assay generates quantitative data of cancer‐related mutations and thus provides insight into pathological processes following carcinogen exposure. Environ. Mol. Mutagen., 2011. © Published 2011 Wiley‐Liss, Inc." @default.
• W2060720121 created "2016-06-24" @default.
• W2060720121 creator A5019247342 @default.
• W2060720121 creator A5035032193 @default.
• W2060720121 date "2011-03-02" @default.
• W2060720121 modified "2023-10-18" @default.
• W2060720121 title "Accumulation of K‐<i>Ras</i> codon 12 mutations in the F344 rat distal colon following azoxymethane exposure" @default.
• W2060720121 cites W1647238192 @default.
• W2060720121 cites W167055734 @default.
• W2060720121 cites W1966264102 @default.
• W2060720121 cites W1973677994 @default.
• W2060720121 cites W1975849224 @default.
• W2060720121 cites W1977113524 @default.
• W2060720121 cites W1995434582 @default.
• W2060720121 cites W1995714303 @default.
• W2060720121 cites W2008006494 @default.
• W2060720121 cites W2013311105 @default.
• W2060720121 cites W2014322052 @default.
• W2060720121 cites W2022532738 @default.
• W2060720121 cites W2026195203 @default.
• W2060720121 cites W2034550393 @default.
• W2060720121 cites W2041657197 @default.
• W2060720121 cites W2043304606 @default.
• W2060720121 cites W2043415570 @default.
• W2060720121 cites W2045341592 @default.
• W2060720121 cites W2049761824 @default.
• W2060720121 cites W2051905728 @default.
• W2060720121 cites W2067089521 @default.
• W2060720121 cites W2081252468 @default.
• W2060720121 cites W2088830247 @default.
• W2060720121 cites W2092741708 @default.
• W2060720121 cites W2095692554 @default.
• W2060720121 cites W2099060406 @default.
• W2060720121 cites W2110151309 @default.
• W2060720121 cites W2120045074 @default.
• W2060720121 cites W2127218675 @default.
• W2060720121 cites W2133120554 @default.
• W2060720121 cites W2140887851 @default.
• W2060720121 cites W2143222961 @default.
• W2060720121 cites W2165976417 @default.
• W2060720121 cites W2167539263 @default.
• W2060720121 cites W2169475799 @default.
• W2060720121 doi "https://doi.org/10.1002/em.20644" @default.
• W2060720121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21370285" @default.
• W2060720121 hasPublicationYear "2011" @default.
• W2060720121 type Work @default.
• W2060720121 sameAs 2060720121 @default.
• W2060720121 citedByCount "15" @default.
• W2060720121 countsByYear W20607201212012 @default.
• W2060720121 countsByYear W20607201212013 @default.
• W2060720121 countsByYear W20607201212015 @default.
• W2060720121 countsByYear W20607201212017 @default.
• W2060720121 countsByYear W20607201212018 @default.
• W2060720121 countsByYear W20607201212019 @default.
• W2060720121 countsByYear W20607201212020 @default.
• W2060720121 crossrefType "journal-article" @default.
• W2060720121 hasAuthorship W2060720121A5019247342 @default.
• W2060720121 hasAuthorship W2060720121A5035032193 @default.
• W2060720121 hasConcept C104317684 @default.
• W2060720121 hasConcept C114246631 @default.
• W2060720121 hasConcept C121608353 @default.
• W2060720121 hasConcept C126322002 @default.
• W2060720121 hasConcept C134018914 @default.
• W2060720121 hasConcept C153911025 @default.
• W2060720121 hasConcept C185592680 @default.
• W2060720121 hasConcept C2776639595 @default.
• W2060720121 hasConcept C2778452354 @default.
• W2060720121 hasConcept C2780669762 @default.
• W2060720121 hasConcept C2781247443 @default.
• W2060720121 hasConcept C3018440083 @default.
• W2060720121 hasConcept C501734568 @default.
• W2060720121 hasConcept C526805850 @default.
• W2060720121 hasConcept C54355233 @default.
• W2060720121 hasConcept C55493867 @default.
• W2060720121 hasConcept C555283112 @default.
• W2060720121 hasConcept C71924100 @default.
• W2060720121 hasConcept C86803240 @default.
• W2060720121 hasConceptScore W2060720121C104317684 @default.
• W2060720121 hasConceptScore W2060720121C114246631 @default.
• W2060720121 hasConceptScore W2060720121C121608353 @default.
• W2060720121 hasConceptScore W2060720121C126322002 @default.
• W2060720121 hasConceptScore W2060720121C134018914 @default.
• W2060720121 hasConceptScore W2060720121C153911025 @default.
• W2060720121 hasConceptScore W2060720121C185592680 @default.
• W2060720121 hasConceptScore W2060720121C2776639595 @default.
• W2060720121 hasConceptScore W2060720121C2778452354 @default.
• W2060720121 hasConceptScore W2060720121C2780669762 @default.
• W2060720121 hasConceptScore W2060720121C2781247443 @default.
• W2060720121 hasConceptScore W2060720121C3018440083 @default.
• W2060720121 hasConceptScore W2060720121C501734568 @default.
• W2060720121 hasConceptScore W2060720121C526805850 @default.
• W2060720121 hasConceptScore W2060720121C54355233 @default.
• W2060720121 hasConceptScore W2060720121C55493867 @default.
• W2060720121 hasConceptScore W2060720121C555283112 @default.
• W2060720121 hasConceptScore W2060720121C71924100 @default.
• W2060720121 hasConceptScore W2060720121C86803240 @default.
• W2060720121 hasIssue "5" @default.
• W2060720121 hasLocation W20607201211 @default.

• next