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- W2060724905 abstract "We have recently demonstrated that a single injection of potent estrogenic compounds, such as 17β-estradiol or diethylstilbestrol, results in two increases in nuclear estrogen receptor in the ovariectomized or immature mouse uterus. These nuclear increases occur 1–2 and 7–8 h post injection. In this study, we have determined whether the weak estrogen estriol could produce both nuclear events and, if so, whether both events were necessary for a complete uterine response in the mouse. Estriol injection of 10 or 33 μg/kg indicated similar nuclear receptor translocation at 1 h, with levels returning near control by 4–5 h. Injections of 166 μg/kg estriol or 10 μg/kg estradiol produced similar patterns of nuclear receptor with comparable increases occurring at ∼1 and 7–8 h. A single 10 μg/kg injection of estradiol resulted in a biphasic increase in uterine wet weight. The first increase was at ∼4 h, with the second occurring at ∼9 h and staying elevated above control values for up to 48 h. Estriol, on the other..." @default.
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- W2060724905 date "1980-06-01" @default.
- W2060724905 modified "2023-09-27" @default.
- W2060724905 title "Differential Response to Estriol and Estradiol in the Mouse Uterus: Correlation to an Additional Nuclear Event" @default.
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- W2060724905 doi "https://doi.org/10.1210/endo-106-6-1900" @default.
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